Registration Dossier
Registration Dossier
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EC number: 930-430-2 | CAS number: 1383692-20-3
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to EU/OECD guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- 1-difluoromethanesulfonyl-3-(4,6-dimethoxy-1,3,5-triazin-2-yl)-7-fluoro-1H-indol-2-ol
- EC Number:
- 930-430-2
- Cas Number:
- 1383692-20-3
- Molecular formula:
- C14H11F3N4O5S
- IUPAC Name:
- 1-difluoromethanesulfonyl-3-(4,6-dimethoxy-1,3,5-triazin-2-yl)-7-fluoro-1H-indol-2-ol
Constituent 1
Results and discussion
Partition coefficientopen allclose all
- Type:
- Pow
- Partition coefficient:
- 1 585
- Temp.:
- 25 °C
- pH:
- 2
- Type:
- Pow
- Partition coefficient:
- 0.8
- Temp.:
- 25 °C
- pH:
- 7
- Type:
- log Pow
- Partition coefficient:
- 3.2
- Temp.:
- 25 °C
- pH:
- 2
- Type:
- log Pow
- Partition coefficient:
- -0.1
- Temp.:
- 25 °C
- pH:
- 7
Applicant's summary and conclusion
- Conclusions:
- The partition coefficients of the test item were at 25 °C:
partition coefficient pH2 pH7
log Pow 3.2 -0.1
Pow 1585 0.8
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