2,4,6-trimethylphenol

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

other: Expert Statement

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: An expert statement based on all available literature data

Qualifier:

no guideline required

Principles of method if other than guideline:

expert statement

GLP compliance:

no

Type of method:

other: An expert statement based on all available literature data

Water solubility:

ca. 1.2 g/L

Temp.:

25 °C

Remarks on result:

other: The average (n = 2) reported water solubility

Reference	Klimisch Code	Temp. (°C)	Water Solubility (g/L)	Method
Varhanickova, Dana; Shiu, Wan-Ying; Mackay, Donald, Aqueous Solubilities of Alkylphenols and Methoxyphenols at 25 °C. J. Chem. Eng. Data (1995), 40(2), 448-51.	2*	25	1.42	HPLC
Blackman, G.E.; Parke, M.H.; Garton, G.; The physiological activity of substituted phenols. II. Relations between physical properties and physiological activity. Arch. Biochem. and Biophys. (1955), 54, 55-71.	2	25	1.01	Colorimetric
Average				1.21
Deviation				0.21
Rel. Dev.				17%

* Reliable with restrictions (Klimisch et al., 1987)

The average (n = 2) reported water solubility of TMP is 1.2±0.2 g/L at 25°C. The reported water solubility data were considered to have a Klimisch code of 2, indicating that they were “well documented and scientifically acceptable”(Klimisch et al., 1987).

REFERENCES

Klimisch H.J.; Andreae M.; Tillmann U.; A systematic approach for evaluating the quality of experimental toxicological and ecotoxicological data. Reg. Toxicol. Pharmacol.(1987), 28, 1-5.

Conclusions:

Interpretation of results (migrated information): soluble (1000-10000 mg/L)
The average (n = 2) reported water solubility of the test substance is 1.2 ± 0.2 g/L at 25 °C.

Key value for chemical safety assessment

Water solubility:

1.2 g/L

at the temperature of:

25 °C