N,N-dimethyl-N'-(2,2,6,6-tetramethylpiperidin-4-yl)propane-1,3-diamine

Ecotoxicological Summary

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:

PNEC aqua (freshwater)

PNEC value:

0.043 mg/L

Assessment factor:

1 000

Extrapolation method:

assessment factor

PNEC freshwater (intermittent releases):

0.431 mg/L

Marine water

Hazard assessment conclusion:

PNEC aqua (marine water)

PNEC value:

0.004 mg/L

Assessment factor:

10 000

Extrapolation method:

assessment factor

STP

Hazard assessment conclusion:

PNEC STP

PNEC value:

18 mg/L

Assessment factor:

10

Extrapolation method:

assessment factor

Sediment (freshwater)

Hazard assessment conclusion:

PNEC sediment (freshwater)

PNEC value:

0.349 mg/kg sediment dw

Extrapolation method:

equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:

PNEC sediment (marine water)

PNEC value:

0.035 mg/kg sediment dw

Extrapolation method:

equilibrium partitioning method

Hazard for air

Air

Hazard assessment conclusion:

no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:

PNEC soil

PNEC value:

0.044 mg/kg soil dw

Extrapolation method:

equilibrium partitioning method

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:

no potential for bioaccumulation

Additional information

The toxicity of the test substance on aquatic organisms was assessed for the standard aquatic trophic levels fish, Daphnia, algae and aquatic microorganisms. The LC50 for green algae was determined to be 65.5 mg/L and for fish an LC50 of 130 mg/L was predicted. For Daphnia magna, the short-term test revealed an EC50 of 43.1 mg/L after 48 h, representing the most sensitive species when being exposed to Triacetonetriamine. The substance has been shown to be not toxic up to a concentration of 180 mg/L to activated sludge of a municipal sewage treatment plant (NOEC= 180 mg/L).

The calculation of PNEC is based on the aquatic test results and the assessment factors recommended in the Technical Guidance Document R.10 (ECHA, 2008) have been applied. No studies for sediment-dwelling or soil organisms have been conducted. Therefore, the PNECs for sediment and soil have been derived by using the equilibrium partitioning method according to the guidance document R.10 (ECHA, 2008) as screening value.

Furthermore, as the log Koc is low, Triacetonetriamine is expected to have a low potential for adsorption. Due to the logKow below 3 (measured logKow=0.58 at 20 °C), Triacetonetriamine is not expected to bioaccumulate.

 

PNEC aquatic

The effect level of freshwater invertebrates, which represents the most sensitive species when exposed to Triacetonetriamine was used for calculation of the PNEC aqua (freshwater) and an assessment factor of 1000 was applied. The same effect level was used for derivation of the PNEC aqua (marine) as no data is available for marine organisms. Here, an assessment factor of 10000 was used.

PNEC STP

 A test on respiration inhibition performed according to guideline OECD TG209 is used for the calculation of the PNEC STP. The no observed effect level was used, resulting in the lowest PNEC and an assessment factor of 10 was applied.

PNEC sediment

As no studies for sediment organisms are available, the PNEC sediment was calculated using the equilibrium partitioning method as a screen for assessing the risk to sediment dwelling organisms. The PNEC_{freshwater sediment}was calculated according to the equation R.10-2 of the guidance on information requirements and chemical safety assessment R.10:

PNEC_{freshwater sed.}= (K_susp-water/RHO_susp)*PNEC_water* 1000

 

PNEC_{freshwater sed.}=(2.022/1150)*0.0431*1000= 0.0758 (wet weight)

PNEC_{freshwater sed.}=0.0758 * 4.6 = 0.3486 mg/kg sediment dw

K_susp-waterwas calculated to be 2.022 based on the equation R.16-7 of the guidance on information requirements and chemical safety assessment R.16; RHO_susp= 1150 and the PNEC_wateris indicated above. The conversion factor from wet weight to dry weight is 4.6.

The PNEC marine water sediment was derived as described according to equation R.10-3 using the PNEC aqua marine water.

As the PEC/PNEC ratio is below 1 in the chemical safety assessment, is it concluded that testing on sediment dwelling organism is not indicated.

PNEC soil

As no studies for soil organisms are available, the PNEC for soil was derived by using the equilibrium partitioning method according to equation R.10-5 of the guidance on information requirements and chemical safety assessment R.10:

PNEC_soil= (K_soil-water/RHO_soil)*PNEC_water* 1000

PNEC_soil=1.5464/1700*0.0431*1000 = 0.0392 (wet weight)

PNEC_soil=0.0392*1.133 = 0.0444 mg/kg soil dw

K_soil-waterwas calculated to be 1.5464 based on the equation R.16-7 of the guidance on information requirements and chemical safety assessment R.16; RHO_soil= 1700 and the PNEC_wateris described above. The conversion factor from wet weight to dry weight is 1.133.

As the ratio of PEC/PNEC for soil does not reach the trigger of >1 in the chemical safety assessment, further testing with soil organisms is not required. Furthermore, the log Kow is below 3 (measured logKow of 0.58 at 20 °C, see point 4.7) and triacetonetriamine is expected to have a low adsorbing potential.

Conclusion on classification

Only short-term toxicity studies on aquatic organisms are available. Daphnia represents the most sensitive species when being exposed to Triacetonetriamine. The acute effect level for Daphnia is EC50=43.1 mg/ L. Furthermore, the test substance is found to be not readily biodegradable. The acute endpoint of the most sensitive species (Daphnia) is in the range between 10 and 100 mg/L. Therefore, the substance should be classified as chronic toxic to aquatic organisms, category 3 (H412) according to Regulation (EC) No. 1272/2008 and, additionally, as acute toxic to the aquatic environment, category 3 (H402) according to UN-GHS (5^thedition).