Registration Dossier
Registration Dossier
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EC number: 203-643-7 | CAS number: 109-06-8
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Experimental study by a reputable industry laboratory, prior to establishment of international guidelines and GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Precedes establishment of guideline and GLP. It is assumed that this scientific study was performed according to the accepted standards of its day.
- GLP compliance:
- no
- Type of study:
- other: guinea pig
Test material
- Reference substance name:
- Pyridine
- EC Number:
- 203-809-9
- EC Name:
- Pyridine
- Cas Number:
- 110-86-1
- Molecular formula:
- C5H5N
- IUPAC Name:
- pyridine
- Details on test material:
- no data
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- other: no data
- Concentration / amount:
- no data
Challengeopen allclose all
- Route:
- other: likely dermal
- Concentration / amount:
- no data
- No. of animals per dose:
- no data
- Details on study design:
- no data provided in this summary
Results and discussion
In vivo (non-LLNA)
Results
- Clinical observations:
- Not sensitising
- Remarks on result:
- other: Clinical observations: Not sensitising.
Any other information on results incl. tables
Not sensitising in guinea pigs.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Alpha picoline (2-methylpyridine) is a member of a chemical category including pyridine and pyridine derivatives. The dermal sensitisation properties of pyridine were studied in the guinea pig, and pyridine was found to be a non-sensitiser. Reading-across from pyridine to this substance is valid for the purposes of classification and risk assessment.
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