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EC number: 262-038-6 | CAS number: 60047-17-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1997
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientific paper conducted on a group on radical Intermediates of Linalyl Hydroperoxide.
Data source
Reference
- Reference Type:
- publication
- Title:
- Skin Sensitization to Linalyl Hydroperoxide: Support for Radical Intermediates
- Author:
- Michael Bezard,† Ann-Therese Karlberg,‡ Johan Montelius,‡ and Jean-Pierre Lepoittevin*,†
- Year:
- 1 997
- Bibliographic source:
- Chem. Res. Toxicol. 1997, 10, 987-993
Materials and methods
- Principles of method if other than guideline:
- The LLNA was carried out as essentially recommended by Kimber and Basketter (12). Female mice (CBA/Ca strain, 6-10 weeks old), in groups of four, received 25 íL of the test chemical dissolved in dimethylformamide (DMF) on the dorsum of both ears for 3 consecutive days.
- GLP compliance:
- no
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Linalool oxide
- EC Number:
- 215-723-9
- EC Name:
- Linalool oxide
- Cas Number:
- 1365-19-1
- IUPAC Name:
- 2-(5-methyl-5-vinyltetrahydrofuran-2-yl)propan-2-ol
- Reference substance name:
- Furan 5
- IUPAC Name:
- Furan 5
- Test material form:
- gas under pressure: refrigerated liquefied gas
- Details on test material:
- Furan and pyran derivatives were prepared according to the literature (21) by epoxidation of linalool with m-CPBA at 0 °C for 4 h (Scheme 3). Furan derivatives 5a,b were predominantly formed (79% yield).
Constituent 1
Constituent 2
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
- Details on test animals and environmental conditions:
- The LLNA was carried out as essentially recommended by Kimber and Basketter (12). Female mice (CBA/Ca strain, 6-10 weeks old), in groups of four, received 25 íL of the test chemical dissolved in dimethylformamide (DMF) on the dorsum of both ears for 3 consecutive days. Test solutions were made fresh each day and applied within 30 min. Compounds 1-6 were tested in three different concentrations: 1%, 3%, and 9% (w/w), respectively. Control mice were treated with an equal volume of DMF alone. Five days after the first treatment, all mice were injected intravenously through the tail vein with 20 íCi of [3H]thymidine (specific activity 2 Ci/mmol; Amersham International, Amersham, U.K.) in 250 íL of phosphate-buffered saline. After 5 h,
the mice were sacrificed, the draining auricular lymph nodes were excised and pooled for each group, and a single-cell suspension of lymph node cells was prepared. After washing and precipitation with trichloroacetic acid, thymidine incorporation was determined by â-scintillation counting (13).
Study design: in vivo (LLNA)
- Vehicle:
- dimethylformamide
- Concentration:
- 1, 3, 9
- No. of animals per dose:
- 4 females
- Details on study design:
- The LLNA was carried out as essentially recommended by Kimber and Basketter (12). Female mice (CBA/Ca strain, 6-10 weeks old), in groups of four, received 25 íL of the test chemical dissolved in dimethylformamide (DMF) on the dorsum of both ears for 3 consecutive days. Test solutions were made fresh each day and applied within 30 min. Compounds 1-6 were tested in three different concentrations: 1%, 3%, and 9% (w/w), respectively. Control mice were treated with an equal volume of DMF alone. Five days after the first treatment, all mice were injected intravenously through the tail vein with 20 íCi of [3H]thymidine (specific activity 2 Ci/mmol; Amersham International, Amersham, U.K.) in 250 íL of phosphate-buffered saline. After 5 h,
the mice were sacrificed, the draining auricular lymph nodes were excised and pooled for each group, and a single-cell suspension of lymph node cells was prepared. After washing and precipitation with trichloroacetic acid, thymidine incorporation was determined by â-scintillation counting (13).
Results and discussion
- Positive control results:
- These results, coming from a combination of chemicaltrapping experiments and in vivo experimental sensitization data, are in favor of the formation of a carboncentered reactive radical as an intermediate in the skin sensitization to linalyl hydroperoxide.
Any other information on results incl. tables
chemical concn (w/w, %) [3H]thymidine incorpn (dpm/node) stimulation index
Linalool Oxide 1.0 139 1.1
3.0 189 1.4
9.0 279 2.1
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Linalool oxide is not a skin sensitiser.
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