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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1988
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: GLP compliant study conducted according to OECD Guidelines, with no deviations.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1988
Report date:
1989

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
Principles of method if other than guideline:
The test has been conducted prior to the current OECD guideline.
GLP compliance:
yes

Test material

Constituent 1
Reference substance name:
Linalool oxide
EC Number:
215-723-9
EC Name:
Linalool oxide
Cas Number:
1365-19-1
IUPAC Name:
2-(5-methyl-5-vinyltetrahydrofuran-2-yl)propan-2-ol
Test material form:
other: liquid
Details on test material:
Sample 980-88, Linalool Oxide (Givaudan)

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
semiocclusive
Preparation of test site:
clipped
Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
0.5 ml
Duration of treatment / exposure:
four hours period
Observation period:
1h, 24h, 48h , 72 hours and 7 days
Number of animals:
4 females were tested

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal: number 318
Time point:
other: 24, 48 and 72 hours
Score:
1.8
Max. score:
2
Reversibility:
not fully reversible within: 7 days
Remarks on result:
other: mean value
Irritation parameter:
erythema score
Basis:
animal: number 322
Time point:
other: 24, 48 and 72 hours
Score:
2
Max. score:
2
Reversibility:
fully reversible within: 7 days
Remarks on result:
other: mean value
Irritation parameter:
erythema score
Basis:
animal: number 334
Time point:
other: 24, 48 and 72 hours
Score:
2
Max. score:
2
Reversibility:
not fully reversible within: 7 days
Remarks on result:
other: mean value
Irritation parameter:
erythema score
Basis:
animal: number 340
Time point:
other: 24, 48 and 72 hours
Score:
2
Max. score:
2
Reversibility:
not fully reversible within: 7 days
Remarks on result:
other: mean value
Irritation parameter:
edema score
Basis:
animal: number 318
Time point:
other: 24, 48 and 72 hours
Score:
0.8
Max. score:
1
Reversibility:
not fully reversible within: 7 days
Remarks on result:
other: mean value
Irritation parameter:
edema score
Basis:
animal: number 322
Time point:
other: 24, 48 and 72 hours
Score:
0.6
Max. score:
1
Reversibility:
fully reversible within: 7 days
Remarks on result:
other: mean value
Irritation parameter:
edema score
Basis:
animal: number 334
Time point:
other: 24, 48 and 72 hours
Score:
0.5
Max. score:
0.5
Reversibility:
fully reversible within: 7 days
Remarks on result:
other: mean value
Irritation parameter:
edema score
Basis:
animal: number 340
Time point:
other: 24, 48 and 72 hours
Score:
0.5
Max. score:
0.5
Reversibility:
fully reversible within: 7 days
Remarks on result:
other: mean value

Applicant's summary and conclusion

Interpretation of results:
slightly irritating
Remarks:
Migrated information Not sufficient for classification Criteria used for interpretation of results: EU
Conclusions:
Although slight irritation is observed, all reactions are fully reversible within 7 days and insufficient for classification.