2-(tetrahydro-5-methyl-5-vinyl-2-furyl)propan-2-ol

Toxicity to aquatic algae and cyanobacteria

Administrative data

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2015

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP compliant study conducted according to OECD Guidelines, with no or minor deviations.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2015

Report date:

2015

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 201 (Alga, Growth Inhibition Test)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method C.3 (Algal Inhibition test)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

Constituent 1

Reference substance name:

2-(tetrahydro-5-methyl-5-vinyl-2-furyl)propan-2-ol

EC Number:

262-038-6

EC Name:

2-(tetrahydro-5-methyl-5-vinyl-2-furyl)propan-2-ol

Cas Number:

60047-17-8

Molecular formula:

C10H18O2

IUPAC Name:

2-(5-methyl-5-vinyltetrahydrofuran-2-yl)propan-2-ol

Test material form:

other: liquid

Details on test material:

Name: Linalool Oxide
Batch No.: PE00097239
Purity: 98.5 % (Sum of cis- and trans- isomers)
Expiry date: 2016-08-27

Please note that although the substance is described in the report with the IUPAC name: 2-(5-methyl-5-vinyltetrahydrofuran-2-yl)propan-2-ol related to the CAS number 1365-19-1, recent analytical data had been determined the substance to be a multi-constituent 2-(tetrahydro-5-methyl-5-vinyl-2-furyl)propan-2-ol related to the CAS number 60047-17-8.

As the chemical manufacturing process has not changed since the report was written, the recent analytical information is relevant to the batch which was tested.

Sampling and analysis

Analytical monitoring:

yes

Test solutions

Vehicle:

no

Details on test solutions:

Five concentrations were tested in a geometrical series with a dilution factor of 1.2 (nominal): 96.0 -116-139 -167 - 200 mg/L. Three replicates were tested for each test item concentration and six replicates for the control.

The concentrations were selected based on the results of a non-GLP preliminary range-finder.

Test organisms

Test organisms (species):

Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)

Details on test organisms:

Pseudokirchneriella subcapitata HINDÄK, SAG 61.81

Study design

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

72 h

Test conditions

Nominal and measured concentrations:

Nominal: 96, 116, 139, 167, 200mg/L

Details on test conditions:

With regard to the volatility of the test item, closed bottles without headspace were used to reduce losses of the test item.

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

72 h

Dose descriptor:

EC50

Effect conc.:

> 200 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth rate

Effect concentrations 2

Duration:

72 h

Dose descriptor:

EC10

Effect conc.:

178 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth rate

Remarks on result:

other: (154-200)

Effect concentrations 3

Duration:

72 h

Dose descriptor:

NOEC

Effect conc.:

116 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth rate

Details on results:

The measured concentrations of Linalool Oxide in the fresh media (0 h) were in the range of 102 to 119 % of the nominal values at all tested concentration levels. The measured concentrations in the old media (72 h) were in the range of 93 to 110 % of the nominal values of all concentrations.
Therefore, all effect values given are based on the nominal test item concentrations of Linalool Oxide.

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

The 72 h-ErC50 for Algae was > 200 mg/L in the test conditions. The corresponding NOEC and EC10 based on growth rate inhibition were 116 and 178 mg/L respectively.