2-(tetrahydro-5-methyl-5-vinyl-2-furyl)propan-2-ol

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2015

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP compliant study conducted according to OECD Guidelines, with no or minor deviations.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2015

Report date:

2015

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

Constituent 1

Reference substance name:

2-(tetrahydro-5-methyl-5-vinyl-2-furyl)propan-2-ol

EC Number:

262-038-6

EC Name:

2-(tetrahydro-5-methyl-5-vinyl-2-furyl)propan-2-ol

Cas Number:

60047-17-8

Molecular formula:

C10H18O2

IUPAC Name:

2-(5-methyl-5-vinyltetrahydrofuran-2-yl)propan-2-ol

Test material form:

other: liquid

Details on test material:

Name: Linalool Oxide
Batch No.: PE00097239
Purity: 98.5 % (Sum of cis- and trans- isomers)
Expiry date: 2016-08-27

Please note that although the substance is described in the report with the IUPAC name: 2-(5-methyl-5-vinyltetrahydrofuran-2-yl)propan-2-ol related to the CAS number 1365-19-1, recent analytical data had been determined the substance to be a multi-constituent 2-(tetrahydro-5-methyl-5-vinyl-2-furyl)propan-2-ol related to the CAS number 60047-17-8..

As the chemical manufacturing process has not changed since the report was written, the recent analytical information is relevant to the batch which was tested.

Sampling and analysis

Analytical monitoring:

yes

Details on sampling:

Exposure concentrations were monitored at the start (0 and 24h) and at the end (24 and 48h) of each renewal period.

Test solutions

Vehicle:

no

Details on test solutions:

A limit concentration of the test item of 125 mg/L was tested, which corresponds to a geometric mean measured test item concentration of 117 mg/L.
The limit concentration was selected based on the results of a non-GLP preliminary range finding test in order to achieve a mean measured test item concentration of at least 100mg/L. In this range-finder test no effects were observed in any of the tested concentration levels.

Test organisms

Test organisms (species):

Daphnia magna

Details on test organisms:

Daphnia magna STRAUS (Clone 5)

Study design

Test type:

semi-static

Water media type:

freshwater

Limit test:

yes

Total exposure duration:

48 h

Remarks on exposure duration:

Immobilisation was determined in all groups after 24 and 48 h.

Test conditions

Nominal and measured concentrations:

Non-GLP range-finder: 100mg/L (nominal) with corresponding measured concentrations ranging from 70.5 to 96.2mg/L; and 10 mg/L (nominal) with correpsonding measured concentrations ranging from 7.05 to 9.99 mg/L.
Definitive Limit Test: 125mg/L (nominal), 117 mg/L (geometric mean measured concentration)

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

> 117 mg/L

Nominal / measured:

meas. (geom. mean)

Conc. based on:

test mat.

Basis for effect:

mobility

Effect concentrations 2

Duration:

48 h

Dose descriptor:

EC10

Effect conc.:

> 117 mg/L

Nominal / measured:

meas. (geom. mean)

Conc. based on:

test mat.

Basis for effect:

mobility

Effect concentrations 3

Duration:

48 h

Dose descriptor:

NOEC

Effect conc.:

> 117 mg/L

Nominal / measured:

meas. (geom. mean)

Conc. based on:

test mat.

Basis for effect:

mobility

Details on results:

At the limit nominal concentration of 125 mg/L of the test item Linalool Oxide, which corresponds to a geometric mean measured test item concentration of 117 mg/L, no effects were observed on Daphnia magna.

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

No effects were observed on Daphnia magna in a limit test performed at a nominal concentration of 125 mg/L of the test item Linalool Oxide, which corresponds to a geometric mean measured test item concentration of 117 mg. Thus the EC50 was determined to be > 117 mg/L.