1-dodecylpyridinium chloride

Density

Link to relevant study record(s)

Reference

Endpoint:

density

Remarks:

density

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Experimental test result performed using standard test guidelines

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

GLP compliance:

no

Type of method:

pour and tap (for solids)

Key result

Type:

pour density

Density:

0.465 g/cm³

Temp.:

28.5 °C

Remarks on result:

other: no other details mentioned

Key result

Type:

tap density

Density:

0.548 g/cm³

Temp.:

28.5 °C

Remarks on result:

other: no other details mentioned

Observation

Method Details		Observations		Remarks if, any
Guideline	OECD 109	1^stReading	2^ndReading	-
Method	Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014	-
Principle of method	Pour Density:It is the ratio of known weight of test item and its volume in graduated glass cylinder. Tap Density: It is the difference between the volume of test item measured before & after tapping in the graduated glass cylinder.	-
Test temperature (°C)	-	28°C	29°C
Atmospheric pressure (in hPa)		965.2	968.9
Weight of test item(m)		20.005	20.004
Volume of measuring cylinder; readability in g		50ml;1ml	50ml;1ml
Volume of test item without tapping (V)		44	42
Volume of test item after tapping ( V1)	After 10 tapping	39	39
	After 50 tapping	36	37
	After 110 tapping	36	37
	After 250 tapping	-	-
	After 500 tapping	-	-
	After 750 tapping	-	-

*ρat=density of air at 27°C and 760 mm Hg pressure=0.001168 g/cm³
**Density of water referred from the Table 1 of the IS method.

CALCULATIONS:

Parameters	Details	Calculated values		Average Density
		1st Calculation	2nd Calculation
Pour Density of test Item (g/cm³)	= m    V	0.4546	0.4762	0.4654
Tap density of test Item (g/cm³)	=m   V1	0.5556	0.5406	0.5481

Conclusions:

The mean pour density and tapped density of test chemical was determined to be 0.4654 g/cm³ and 0.5481 g/cm³ at 28.5°C and 967.0 hPa.

Executive summary:

The density of test chemical was determined following OECD guideline 109 and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014.The mean pour density and tapped density of the test item was determined to be 0.4654 g/cm³ and 0.5481 g/cm³at 28.5°C and 967.0 hPa.

Description of key information

The density of test chemical was determined following OECD guideline 109 and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014.The mean pour density and tapped density of the test item was determined to be 0.4654 g/cm³ and 0.5481 g/cm³at 28.5°C and 967.0 hPa.

Key value for chemical safety assessment

Relative density at 20C:

0.548

Additional information

The density of test chemical was determined following OECD guideline 109 and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014.The mean pour density and tapped density of the test item was determined to be 0.4654 g/cm³ and 0.5481 g/cm³at 28.5°C and 967.0 hPa.

From other reliable sources, density of the test chemical was observed to be 0.982 g/cm3 at 25 Deg C.