Tridecan-1-ol

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from peer reviewed journal

Data source

Reference

Reference Type:

publication

Title:

Acute Toxicity to the rat

Author:

SCALA et al.

Year:

1973

Bibliographic source:

American Industrial Hygiene Association Journal

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: refer below principle

Principles of method if other than guideline:

Acute Dermal toxicity of test chemical in rabbit.

GLP compliance:

not specified

Test type:

other: not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Tridecan-1-ol

EC Number:

203-998-8

EC Name:

Tridecan-1-ol

Cas Number:

112-70-9

Molecular formula:

C13H28O

IUPAC Name:

tridecan-1-ol

Details on test material:

- IUPAC Name: 1-Tridecanol
- InChI: 1S/C13H28O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14/h14H,2-13H2,1H3
- Smiles: C(CCCCCCO)CCCCCC
- Molecular formula:C13H28O
- Molecular weight:200.3632 g/mole
- Substance type:Organic

Specific details on test material used for the study:

- IUPAC Name: 1-Tridecanol
- InChI: 1S/C13H28O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14/h14H,2-13H2,1H3
- Smiles: C(CCCCCCO)CCCCCC
- Molecular formula:C13H28O
- Molecular weight:200.3632 g/mole
- Substance type:Organic

Test animals

Species:

rabbit

Strain:

other: Albino

Sex:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
Housing: The animals were housed individually
Diet (e.g. ad libitum):ad libitum
Water (e.g. ad libitum): ad libitum

Administration / exposure

Type of coverage:

occlusive

Vehicle:

not specified

Details on dermal exposure:

TEST SITE
- Area of exposure: the closely clipped, intact abdominal skin
- Type of wrap if used: The exposed area was covered with an occlusive binding of dental damming
REMOVAL OF TEST SUBSTANCE
- Washing (if done): After the exposure, the binding was removed, and the remaining material, if any, was cleaned from the skin.
- Time after start of exposure:24 hour

Duration of exposure:

24 hours

Doses:

0.10, 0.316, 1.00, and 3.16 ml/kg were administered volumetrically.

No. of animals per sex per dose:

groups of 4 (sex not mentioned)

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: Observations for signs of toxicity were made frequently on the day of application and once daily afterward for a total of 7 days.
Necropsy of survivors performed: yes/no: Yes, Gross necropsies were performed at the end of the experiments.

Statistics:

The results have been converted to gravimetric expressions by use of the specific gravity.

Results and discussion

Preliminary study:

not specified

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 2 600 mg/kg bw

Based on:

test mat.

Remarks on result:

other: Dose reported is the highest dose tested

Mortality:

No Mortality observed at 2600 mg/kg bw.

Clinical signs:

other: No signs of toxicity observed

Gross pathology:

No data

Other findings:

On observation of the binders after 24 hours of skin contact, percutaneous absorption was evident with all the alcohols even though the median lethal dose was not achieved.

Any other information on results incl. tables

 

Table: Acute dermal toxicity of alcohols

Alcohol	LD50 (gm/kg)	Signs
Tridecyl	>2.6	None

 

Applicant's summary and conclusion

Interpretation of results:

other: Not classified

Conclusions:

Acute dermal toxicity dose (LD50) was considered to be >2600 mg/kg bw, when groups of 4 albino rabbits were treated with test chemical by dermal application occlusively to the closely clipped, intact abdominal skin for 24 hours.

Executive summary:

Acute dermal toxicity study was conducted by using test chemical in groups of 4 albino rabbits at the dose concentration of 0.10, 0.316, 1.00, and 3.16 ml/kg bw administered volumetrically. The animals were housed individually with feed and water freely available. No mechanical restraints were used.The test chemical was applied full-strength to the closely clipped, intact abdominal skin of albino rabbits. The exposed area was covered with an occlusive binding of dental damming for 24 hours. After the exposure, the binding was removed, and the remaining material, if any, was cleaned from the skin. Observations for signs of toxicity were made frequently on the day of application and once daily afterward for a total of 7 days. Gross necropsies were performed at the end of the experiments. The results have been converted to gravimetric expressions by use of the specific gravity. No Mortality observed at 2600 mg/kg bw. No signs of toxicity observed. On observation of the binders after 24 hours of skin contact, percutaneous absorption was evident with the chemical even though the median lethal dose was not achieved. Therefore, LD50 was considered to be >2600 mg/kg bw, when groups of 4 albino rabbits were treated with test chemical by dermal application occlusively to the closely clipped, intact abdominal skin for 24 hours.