Registration Dossier
Registration Dossier
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EC number: 232-318-2 | CAS number: 8003-22-3 This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 47000.
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
According to the study [14C] DCY was rapidly distributed, metabolized, and excreted by rats. In 24 h after intravenous dosing, rats excreted 81.1% of the dose in the feces and 16.0% of the dose in the urine. For rats fitted with biliary cannulas, 54.5% of the dose, all of which was metabolites of [14C]DCY, was recovered in the bile 4 h. Associated with the rapid and extensive biliary excretion of metabolites of intravenously administered I14C]DCY was the appearance of large amounts of radioactivity in the feces and also, at intermediate time points, in the liver, gut contents, and gut tissue. In conclusion, rats rapidly distribute, metabolize, and excrete [14C]DCY. Since no toxic effects were evident, this study has provided no basis for assuming that exposure to small amounts of DCY would be hazardous to the health of humans.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
According to the study [14C] DCY was rapidly distributed, metabolized, and excreted by rats. In 24 h after intravenous dosing, rats excreted 81.1% of the dose in the feces and 16.0% of the dose in the urine. For rats fitted with biliary cannulas, 54.5% of the dose, all of which was metabolites of [14C]DCY, was recovered in the bile 4 h. Associated with the rapid and extensive biliary excretion of metabolites of intravenously administered I14C]DCY was the appearance of large amounts of radioactivity in the feces and also, at intermediate time points, in the liver, gut contents, and gut tissue. In conclusion, rats rapidly distribute, metabolize, and excrete [14C]DCY. Since no toxic effects were evident, this study has provided no basis for assuming that exposure to small amounts of DCY would be hazardous to the health of humans.
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