1-(3-chloropropyl)-1,3-dihydro-2H-benzimidazol-2-one

Explosiveness

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

explosive properties of explosives

Type of information:

other: Expert statement

Adequacy of study:

supporting study

Study period:

27 July - 02 December 2015

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Expert statement following no specific guideline and without detailed description of results.

Qualifier:

no guideline followed

Principles of method if other than guideline:

Expert statement.

GLP compliance:

no

Specific details on test material used for the study:

- Batch n°: A14JB3422
- Analytical purity (acid titration): 99.9%
- Expiration date: 30 September 2016
- Storage condition: at room temperature

None of the components of the test item does contain chemical groups which are associated with explosive properties. The molecular structures of any impurities =<1% were not taken into account. In conclusion, JNJ-119717-AAA (T001036) has no explosive properties.

Interpretation of results:

GHS criteria not met

Conclusions:

It is concluded that the substance T001036 does not have explosive properties.

Reference 2

Endpoint:

explosive properties of explosives

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: The test is performed according to EC guideline with some small deviations. However, there is no information on purity of the substance.

Qualifier:

according to guideline

Guideline:

EU Method A.14 (Explosive properties)

Deviations:

yes

Remarks:

1)The weight of the falling hammer is 5 kg and dropped from 0.8 m, however, the energy applied is the same as guideline, 40 J or 40 Nm. 2) In contrast to the EC guideline aluminium foil is used to pack the substance. 3) Ten tests are performed.

GLP compliance:

not specified

Parameter:

sensitiveness to impact: impact energy (J)

Remarks on result:

not sensitive to impact using an impact energy of 40 J

Remarks:

Shock sensitivity > 39.2 Nm, 10 times negative.

Results:

-10 times negative, not shock sensitive (sensitivity > 39.2 Nm).

Interpretation of results:

other: not sensitive to impact

Conclusions:

The test substance is not shock sensitive (sensitivity > 39.2 Nm).

Reference 3

Endpoint:

explosive properties of explosives

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because there are no chemical groups present in the molecule which are associated with explosive properties

Description of key information

Based on a GLP study (WIL Research Europe, 2016), T001036 is considered not to contain any chemical groups indicative for explosive properties. Further testing was omitted and T001036 is concluded not to have explosive properties.

Key value for chemical safety assessment

Explosiveness:

non explosive

Additional information

A supporting study (PSC, 1985) investigated the sensitivity to impact of T001036 following the Lütolf falling hammer method. The substance was found to be not shock sensitive (> 39 Nm). The study was assigned a Klimisch 4 score.

Justification for classification or non-classification

T001036 does not need to be classified as explosive as based on the chemical structure the substance does not contain any chemically instable or highly energetic groups that might lead to an explosion.