Warfarin

Adsorption / desorption

Administrative data

Endpoint:

adsorption / desorption

Type of information:

experimental study

Adequacy of study:

supporting study

Data source

Reference

Reference 1

Reference Type:

review article or handbook

Title:

Unnamed

Year:

2009

Report date:

2009

Reference 2

Reference Type:

secondary source

Title:

Unnamed

Year:

1999

Materials and methods

Principles of method if other than guideline:

Method data are not available as the report details are unpublished.

GLP compliance:

yes

Media:

soil

Test material

Test material information

Constituent 1

Reference substance name:

Warfarin

EC Number:

201-377-6

EC Name:

Warfarin

Cas Number:

81-81-2

Molecular formula:

C19H16O4

IUPAC Name:

4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one

Results and discussion

Any other information on results incl. tables

Soil type	Ka (=KF)	KaOC (=KFOC)	Kd (for 2nd desorption)
Silty clay loam	0.66	18	3.64
Sandy silt loam	8.51	247	8.56
Silty clay loam	0.65	42	3.44
clay loam	46.77	390	50.39

 

Kf 14.15, range 0.66 – 46.77, n=4

Koc 174, range 18 – 390, n=4

 

Warfarin adsorption strongly depends on pH and organic matter content. Adsorption increases with decreasing soil pH.

Applicant's summary and conclusion

Conclusions:

Kf 14.15, range 0.66 – 46.77, n=4
Koc 174, range 18 – 390, n=4

Warfarin adsorption strongly depends on pH and organic matter content. Adsorption increases with decreasing soil pH.