Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 426-200-1 | CAS number: 172015-79-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V (B1 bis)
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
Test animals
- Species:
- other: Rat (Wistar)
Administration / exposure
- Vehicle:
- other: Distilled water
- No. of animals per sex per dose:
- Preliminary sighting study: 2 (male)
Preliminary sighting study: 2 (female)
Main study: 5 (male)
Main study: 5 (female)
Results and discussion
- Preliminary study:
- Species/strain: Rat (Wistar)
mg/kg bw: Evident toxicity: ; Mortality:
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- discriminating dose
- Effect level:
- 50 mg/kg bw
- Dose descriptor:
- other: 50 mg/kg bw (fixed dose initial)
- Remarks on result:
- other: No. with evident toxicity: ; No. of deaths: ; No. of animals used:
- Dose descriptor:
- other: 50 mg/kg bw (fixed dose initial)
- Remarks on result:
- other: No. with evident toxicity: ; No. of deaths: 0; No. of animals used: 5
- Clinical signs:
- other: Signs of toxicity: In a preliminary study one male animal died 6 hours after dosing with 500 mg/kg. Clinical signs of toxicity observed in one male and one female were hunched posture, lethargy, pilo-erection, decreased respiratory rate ataxia and in
- Gross pathology:
- Effects on organs:
There were no pathological abnormalitites noted at necropsy
in the main study.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
