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EC number: 246-058-2 | CAS number: 24170-60-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 January 1984
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- N-[2-[(2-cyano-4,6-dinitrophenyl)azo]-5-(diethylamino)phenyl]acetamide
- EC Number:
- 246-058-2
- EC Name:
- N-[2-[(2-cyano-4,6-dinitrophenyl)azo]-5-(diethylamino)phenyl]acetamide
- Cas Number:
- 24170-60-3
- Molecular formula:
- C19H19N7O5
- IUPAC Name:
- N-{2-[(2-cyano-4,6-dinitrophenyl)diazenyl]-5-(diethylamino)phenyl}acetamide
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- None
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch number of test material: EN 43'693.12
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Stability under test conditions: until October 1988
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Kleintierfarm Madoerin AG, CH-4414 Fuellinsdorf
- Age at study initiation: 12 - 14 weeks
- Weight at study initiation: 2240-2390 g
- Housing: Animals were housed individually in metal cages.
- Diet: Rabbit food, NAFAG, No. 814 Tox, NAFAG AG, Gossau, SG (Switzerland) ad liitum
- Water: water ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/-3
- Humidity (%): 30-70
- Air changes (per hr): approximately 15 air changes/h
- Photoperiod (hrs dark / hrs light): 12 hours light/day
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Remarks:
- Using electric clipper
- Vehicle:
- water
- Remarks:
- The substance was water moistened before application
- Controls:
- no
- Amount / concentration applied:
- 0.5 g of the test substance was applied.
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 7 days
- Number of animals:
- 3 females
- Details on study design:
- - Application of the Substance: Not less than 24 hours before treatment on the back of the experimental animal an area was shaven of at least 6 sq. cm, by means of an electric clipper. A gauze patch bearing 0.5 g of the test substance was applied to the skin and loosely held in place by adhesive but non-irritating tape (ISOPLAST AG, CH-5200 Brugg). The substance was water moistened before application.
SCORING SYSTEM:
Evaluation of the dermal reactions.
Erythema and Eschar formation:
- No erythema: 0
- Very slight erythema: 1
- Well defined erythema: 2
- Moderate to severe erythema: 3
- Severe erythema (beet redness) to slight eschar formation: 4
- Corrosion: +
Oedema formation:
- No oedema: 0
- Very slight oedema: 1
- Slight oedema: 1
- Slight oedema (edges of area well defined by definite raising) 2
- Moderate oedema (approx. 1mm): 3
- Severe oedema (raised more than 1 mm, extended beyond. appl. site): 4
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- 3 rabbits
- Time point:
- 24/48/72 h
- Max. score:
- 4
- Remarks on result:
- not determinable
- Remarks:
- Due to intensive blue staining by the test substance a scoring of the erythema values was not possible
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- 3 rabbits
- Time point:
- 24/48/72 h
- Score:
- 0.56
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 d
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Remarks:
- 3 rabbits
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Reversibility:
- fully reversible within: 7 d
- Other effects:
- Due to intensive blue staining by the test substance a scoring of the erythema values was not possible.
The dermal irritation was evaluated after the score for oedema formation only.
The animals showed a normal body weight development.
Any other information on results incl. tables
Scoring of erythema and eschar formation:
Animal No. / Sex | 1 hr | 24 hrs | 48 hrs | 72 hrs | 7 days | |
22 / F | * | * | * | * | * | |
23 / F | * | * | * | * | * | |
24 / F | * | * | * | * | * | |
Total | * + | * + | * + | * = | * | (A) |
Scoring of Oedema formation:
Animal No. / Sex | 1 hr | 24 hrs | 48 hrs | 72 hrs | 7 days | |
22 / F | 1 | 1 | 1 | 1 | 0 | |
23 / F | 0 | 0 | 0 | 0 | 0 | |
24 / F | 2 | 1 | 1 | 0 | 0 | |
Total | 3 + | 2 + | 2 + | 1 = | 8 | (B) |
Index of skin irritation: A* + B = 1.33
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- FAT 36156/A is non irritant when applied to the rabbit skin.
- Executive summary:
The study was performed to determine the acute dermal irritation/corrosion potential of FAT 36156/A on New Zealand rabbits according to the OECD guideline 404. Three female rabbits were used in the test; 0.5 g of the test item was applied to the skin of the rabbit which was shaved not less than 24 hours before the application. The exposure duration was 4 hours. After removal of the dressing, the skin reaction was assessed (for erythema and oedema) after 1, 24, 48, 72 hours and during the 7 days of observation period. The animals showed a normal body weight development. Due to intensive blue staining by the test substance, the scoring of the erythema values was not possible. The dermal irritation was evaluated after the score for oedema formation only. The calculated dermal irritation index was 1.33 for oedema. The animals had recovered at the end of the observation period of 7 days. Under the conditions of the present experiment, FAT 36156/A was found to be slightly irritant and not corrosive when applied to the rabbit skin. However, as per the Regulation (EC) No. 1272/2008, it does not need to be classified.
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