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EC number: 240-816-6 | CAS number: 16753-62-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 January to 7 February 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study was conducted according to an appropriate guideline and in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 016753-21
- IUPAC Name:
- 016753-21
- Reference substance name:
- Dimethoxymethylvinylsilane
- EC Number:
- 240-816-6
- EC Name:
- Dimethoxymethylvinylsilane
- Cas Number:
- 16753-62-1
- Molecular formula:
- C5H12O2Si
- IUPAC Name:
- ethenyldimethoxymethylsilane
- Reference substance name:
- dimethoxy(methyl)vinylsilane
- IUPAC Name:
- dimethoxy(methyl)vinylsilane
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): Dow Corning X1-2349 Intermediate MeViSi(OMe)2
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Taconic Farms, US
- Age at study initiation: 6-7 weeks
- Weight at study initiation: 102-117g (males), 97-107g (females)
- Fasting period before study: no
- Housing: stainless steel cages
- Diet (ad libitum): PMI Rodent Chow 5002 (PMI Feed Inc, US)
- Water (ad libitum): municipal tap water
- Acclimation period: 6 days
ENVIRONMENTAL CONDITIONS
- Temperature: 66 to 75 degrees F
- Humidity (%): 30 to 56
- Air changes (per hr): not stated
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: To: 24 January to 7 February 1996
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: stainless steel and glass Rochester-type inhalation chamber
- Exposure chamber volume: 500 L
- Method of holding animals in test chamber: not stated
- System of generating vapour: compressed air-operated Laskin nebuliser
- Source and rate of air: room air
- Method of conditioning air: filtered
- Treatment of exhaust air: passed through activated carbon and HEPA filters
- Temperature, humidity, pressure in air chamber: temp 69 to 72 degrees F, RH 30 to 41%,
TEST ATMOSPHERE
- Brief description of analytical method used: infrared analyser
- Samples taken from breathing zone: yes - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 5.00 mg/l
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observed approximately 15 minutes after removal from exposure chamber and daily thereafter. Weighed on day of dosing, Days 7 and 14
- Necropsy of survivors performed: yes - Statistics:
- Means and standard deviations
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- None
- Clinical signs:
- other: none
- Body weight:
- No effect
- Gross pathology:
- No remarkable findings
Any other information on results incl. tables
Test Atmosphere Monitoring (performed with calibrated infrared analyser)
Sample Number |
IR Outputa |
Concentrationb |
1 |
0.518 |
4.99 |
2 |
0.526 |
5.07 |
3 |
0.515 |
4.96 |
4 |
0.517 |
4.98 |
|
Mean |
5.00 |
a 15 minute average of IR output (VDC) using averaging multimeter
b Concentration (mg/L) = IR output (VDC) x 9.633
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- All animals survived 4 hour exposure at 5 mg/L, therefore the LC50 is greater than 5 mg/mL (5000 mg/m3)
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