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EC number: 700-488-1 | CAS number: 873888-84-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2009
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The test consists of a topical exposure of the neat test item to a human reconstructed epidermis model followed by a cell viability test. Cell viability is measured by dehydrogenase conversion of MTT [3,4,5.dimethyl thiazole 2-yl) 2,5-diphenyl-tetrazoliumbromide], present in cell mnithocondria, into a blue formazan salt that is quantitatively measured after extraction from tissues. The percent reduction of cell viability in comparison of untreated negative controls is used to predict skin irritation potential.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- (4Z)-hept-4-en-2-yl salicylate
- EC Number:
- 700-488-1
- Cas Number:
- 873888-84-7
- Molecular formula:
- C14H18O3
- IUPAC Name:
- (4Z)-hept-4-en-2-yl salicylate
Constituent 1
Test animals
- Species:
- other: tissue of skin model EpiSkin
Test system
- Type of coverage:
- open
- Vehicle:
- unchanged (no vehicle)
- Duration of treatment / exposure:
- 15 min
Results and discussion
Any other information on results incl. tables
This in vitro study was performed to assess the potential of Gr-86 -3792 by means of the Human Skin Model Test.
Three tissues of the human skin model EpiSkin were treated with either the test item, the negative control or the positive control for 15 min.
15 microL of the test item were applied to each tissue spread to match the tissue size.
15 microL of either the negative control (deionised water) or the positive control (5% sodium Lauryl sulfate) were applied to each tissue.
After treatment with the negative control induced a sufficient decrease in the relative absorbance as compared to the negative control for the 15 min treatment interval thus ensuring the validity of the test system.
After treatment with the test item GR-86 -3792 the relative absorbance valuees were decreased to 88.2%. This value is well above above the threshold for irritancy of <= 50%.Therefore, the test item is not considered to possess an irritant potential.
In conclusion, it can be stated that in this study and under the experimental conditions reported, the test item GR-86 -3792 is non irritant to skin.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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