Registration Dossier
Registration Dossier
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EC number: 221-877-8 | CAS number: 3266-23-7
Endpoint summary
Administrative data
Key value for chemical safety assessment
Justification for classification or non-classification
No data/information are available for this endpoint.
Ethylene oxide (CAS: 75-21-8) was tested for effects on reproduction in rats (one-generation study). Male and female rats were offered inhalation/vapour concentrations of 10, 33 or 100 ppm for 6 hours per day and 5 days per week. No treatment-related effects were noted in either the dams exposed to 33 or 10 ppm of ethylene oxideor in their litters. Consequently, exposure of rats to 33 ppm of ethylene oxide is considered to be a non-ill effect exposure level for one generation of reproduction.
NIOSH (1981) reported about the teratologic assessment of butylene oxide, styrene oxide and methyl bromide. Rats were offered via inhalation (vapour) concentrations of 250 and 1000 ppm of 1,2-epoxybutane (CAS: 106-88-7) for 7 hours per day and 5 days per week on days 1 - 19 of gestation. There was little indication of maternal toxicity of 1,2-epoxybutane in the rat other than relatively trivial effects on weight gain and a few organ weights. Rabbits were offered 1,2-epoxybutane inhalation (vapour) concentrations of 250 and 1000 ppm for 7 hours per day and 5 days per week from day 1 - 24 of gestation. A few detectable embryotoxic effects of 1,2-epoxybutane occurred in the rabbit at the concentration which was maternally lethal.
The study with ethylene oxide does not indicate a selective reproductive toxicity though the genotoxic potential of ethylene oxide in the gonades is clearly established. It is therefore assumed that also 2,3-epoxybutane is devoid of selective reproductive effects. Moreover, the potential carcinogenicity of the material precludes a designed exposure to levels that might become relevant in terms of reproductive effects.
No classification proposal for 2,3-epoxybutane can be made.
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