Registration Dossier
Registration Dossier
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EC number: 221-877-8 | CAS number: 3266-23-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was conducted prior to GLP and guidelines but sufficient data is available for the interpretation of study results
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 958
- Report date:
- 1958
Materials and methods
- Principles of method if other than guideline:
- Range-finding tests
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1,2-epoxybutane
- EC Number:
- 203-438-2
- EC Name:
- 1,2-epoxybutane
- Cas Number:
- 106-88-7
- Molecular formula:
- C4H8O
- IUPAC Name:
- 2-ethyloxirane
- Details on test material:
- Identified by Passed No. S 252 438
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Male albino New Zealand strain rabbits, 3 to 5 months of age and averaging 2.5 kg in weight were immobilized in a hood to prevent inhalation of vapor during the 24-hour skin contact period. The rabbits were procured locally and maintained on Rockland rabbit ration.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Male rabbits were immobilized in a hood to prevent inhalation of vapor during the 24-hour skin contact period. Thereafter, the polyethylene sheeting used to retain the dose in contact with the clipped skin of the trunk was removed and the animals were caged for the remainder of the 14-day observation period.
- Duration of exposure:
- 24 hour
- Doses:
- 1.25 or 2.5 ml/kg bw
- No. of animals per sex per dose:
- 4/dose
- Control animals:
- no
- Statistics:
- The moving average method of calculating the LD50 was used.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1.77 mL/kg bw
- Mortality:
- 3/4 died at 2.5 ml /kg and 1/4 died at 1.25 ml/kg
- Clinical signs:
- other: The covered applications caused marked erythema and necrosis of the skin which healed with scab formation.
- Gross pathology:
- Lungs of victims sometimes had petechial hemorrhages, livers were pale or mottled, kidneys pale as were also the stomachs.
Applicant's summary and conclusion
- Conclusions:
- By skin penetration the LD50 for rabbits is 1.77 (1.09 to 2.86 ) ml/kg.
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