Registration Dossier
Registration Dossier
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EC number: 221-877-8 | CAS number: 3266-23-7
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: CO2-Headspace Test according to ISO 14593 (Draft, 1996)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,2-epoxybutane
- EC Number:
- 203-438-2
- EC Name:
- 1,2-epoxybutane
- Cas Number:
- 106-88-7
- Molecular formula:
- C4H8O
- IUPAC Name:
- 2-ethyloxirane
- Details on test material:
- CHEMICAL NAME: 1,2-epoxybutane
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - activated sludge from laboratory wastewater plants treating municipal sewage
- concentration of dry substance: 4 mg/L - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 34 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- CO2 evolution
Reference substance
- Reference substance:
- aniline
Results and discussion
% Degradationopen allclose all
- Parameter:
- % degradation (CO2 evolution)
- Remarks:
- ca.
- Value:
- 5
- Sampling time:
- 7 d
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 25
- Sampling time:
- 14 d
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 73
- Sampling time:
- 21 d
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 80 - 90
- Sampling time:
- 28 d
- Details on results:
- - duration of lag phase: ca. 8 -10 days
- duration of degradation phase: ca. 19 - 20 days
- degradation degree in the inhibition control at the end of the test: 80-90 % TIC
- elimination degree in the inhibition control at the end of the test: 90-100 % DOC
- physical-chemical (abiotic) elimination of the test substance at the end of test: - physical-chemical (abiotic) elimination of the test substance at the end of test: <10 % DOC
VALIDITY CRITERIA
- max. deviation of the degradation degree of the test substance in replicates at the end of the test < 20 %: yes
- degradation degree of the reference substance >60 % TIC after 14 days: yes
- inhibition of the inoculum at the test concentration: no
- TIC-value (mg/I) of the blank after 28 days <15 % of the amount of test substance added initially (mg ThIC/I): yes
BOD5 / COD results
- Results with reference substance:
- Kinetic of control substance (in %):
= 68 after 7 day(s)
= 96 after 21 day(s)
Applicant's summary and conclusion
- Interpretation of results:
- readily biodegradable
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