Registration Dossier
Registration Dossier
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EC number: 201-302-7 | CAS number: 80-70-6
Endpoint summary
Administrative data
Description of key information
- LD50 oral, rat = 835 mg/kg bw
- no acute inhalation or dermal toxicity
data available
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 835 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute oral toxicity:
An acute oral toxicity study was performed in year 1982 according to the standard acute method. This study was undertaken to determine the oral median lethal dose (LD50) of tetramethylguanidine in Wistar rats. The major pathological findings noted at necropsy were associated with the stomach, gastrointestinal tract and lungs. Data on the irritancy of the test article and the extreme alkalinity of the test article formulations suggest a severe irritant or corrosive effect on the intestinal linings and tissues with the delayed deaths being possibly due to resultant peritonitis. The LD50 was calculated using a probit method. The calculated value for male and female rats is 835 mg/kg bw.
Acute inhalation and dermal toxicity:
No data available. According to the REACH regulation (EC) 1907/2006, Annex VIII, 8.5. column 2 no further acute toxicity testing is neccessary. because the substance is classified as corrosive to the skin.
Justification for classification or non-classification
With an oral LD50 in rats of 835 mg/kg bw, tetramethylguanidine is classified as Acute Tox Oral 4, H302 according to Regulation (EC) 1272/2008.
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