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Diss Factsheets
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EC number: 400-830-7 | CAS number: 104810-48-2 EVERSORB 80; TINUVIN 1130; TINUVIN 213
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- A mixture of: α-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyl-ω-hydroxypoly(oxyethylene); α-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyl-ω-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyloxypoly(oxyethylene)
- EC Number:
- 400-830-7
- EC Name:
- A mixture of: α-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyl-ω-hydroxypoly(oxyethylene); α-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyl-ω-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyloxypoly(oxyethylene)
- Cas Number:
- 104810-48-2
- Molecular formula:
- (C2H4O)nC38H40N6O5
- IUPAC Name:
- A mixture of: α-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyl-ω-hydroxypoly(oxyethylene); α-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyl-ω-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyloxypoly(oxyethylene)
Constituent 1
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Only limited data has been provided by ECHA and it is difficult to make a full toxicokinetic assessment. In accordance with the Guidance on Information Requirements and Chemical Safety Assessment, Chapter R.7C paragraph R.7.12 (Endpoint specific Guidance), having molecular weight of > 600 g/mol, low solubility in water of 7 mg/L (CIBA-GEIGY S.A.4002 BASEL, 1986) and a likely log Kow value of < 0 (CIBA SDS, published data), the substance is not favorable for penetration across biological membranes. The test substance has very low vapor pressure (0.000048 Pa at 25 °C) (CIBA-GEIGY S.A.4002 BASEL, 1986 (f)), so the potential for the generation of inhalable forms is low; exposure to humans via the inhalation route is also unlikely to occur.
Oral/GI absorption
The hydrolysis data (t1/2: 7.5 days at pH 4) indicates the substance is very stable. No data is available regarding test conducted at lower pHs. There was no evidence of systemic toxicity reported in the data provided from the acute oral studies (CIBA-GEIGY S.A.4002 BASEL, 1986(c)). There were no adverse effects at 5000 mg/kg as a single oral dose. Signs of toxicity observed in the 28-day and 90-day oral toxicity studies would suggest that absorption does take place orally (CIBA-GEIGY S.A.4002 BASEL, 1986(d, e)). A 28 day study indicted liver damage (necrotic foci) at 50 mg/kg. A sub-chronic oral toxicity study indicated increased liver weight, specifically in males. Clinical chemistry results indicated an increase in liver enzymes confirming this organ as a target for toxicity.
Respiratory absorption-Inhalation
There was no evidence of systemic toxicity reported in the data provided on the acute Inhalation (CIBA-GEIGY S.A.4002 BASEL, 1986(g)). When taking into account the determined melting range of <-20°C and the very low vapour pressure of 4.8×10-5 Pa (CIBA-GEIGY S.A.4002 BASEL, 1986(f)) at 25°C, evaporation of Chiguard 5530 into air is not likely to happen.
Dermal absorption
In the acute dermal study in rats, no signs of systemic toxicity were observed (CIBA-GEIGY S.A.4002 BASEL, 1986(h)). The in vivo skin irritation study in rabbit shows that the substance is not a skin irritant (CIBA-GEIGY S.A.4002 BASEL, 1986(i)). The sensitizing potential of Chiguard 5530 has been investigated by a Annex V (Maximisation test). The substance was considered to be a strong skin sensitiser in this test (CIBA-GEIGY S.A.4002 BASEL, 1986 (a)). The substance is surface active (50.5 mN/m) (CIBA-GEIGY S.A.4002 BASEL, 1986 (b)) so this may facilitate enhanced dermal exposure to the substance, which would not be indicated by the physicochemical properties above (e.g. molecular weight, log Kow). - Details on distribution in tissues:
- Systemic effects were observed in the 28-day and 90-day oral toxicity study with liver effects (CIBA-GEIGY S.A.4002 BASEL, 1986(d, e)). It is therefore possible to conclude that the substance, or the metabolites, are transported.
- Details on excretion:
- There is no evidence to indicate the route of excretion of the substance. Any test material that is not absorbed will be excreted in the faeces.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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