Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 210-519-6 | CAS number: 617-52-7
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Overcompensated by rapid and ready biodegradability, thus not relevant
Key value for chemical safety assessment
Additional information
No GLP-compliant experimental study data on hydrolysis as a function of pH are available and testing, required in Annex VIII, column 1, section 9.2.2.1. has been waived in accordance with column 2 restrictions.
Preliminary investigational work performed in the study of investigating toxicity to aquatic plants other than algae (Vryenhoef 2014, Harlan Laboratories Study No. 41301815) indicated that the submission item was hydrolytically stable over a 7-Day test period (initial pH 6.6). Abiotic transformation by hydrolysis is thus expected to be by far overcompensated by rapid and ready biodegradation showing 90 % degradation at day 7 (Harlan Laboratories Study No. D32045). Additionally there is experimental (in vitro) evidence for bio-hydrolysis of the submission item by a microbial enzyme. Smeets & Kieboom (1992, study reported in the toxicokinetics section) used a stereoselective carboxyesterase from an ubiquitary gram-positive eubacterium (Bacillus subtilus), preferably occurring in soil but present in water and air as well, to hydrolyse racemic esters. 63 % of the submission item was converted within 430 min to mono- and diacid metabolites.
In conclusion Hydrolysis is considered an irrelevant process in the environment and no data are necessary for the environmental fate and pathway assessment of the submission item.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
