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Diss Factsheets

Physical & Chemical properties

Water solubility

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Link to relevant study record(s)

Description of key information

Very or „highly soluble“

Key value for chemical safety assessment

Water solubility:
35.1 g/L
at the temperature of:
20 °C

Additional information

The water solubility of the submission item Dimethyl itaconate (CAS 617-52-7) was investigated in a GLP-compliant study (Walker 2014, Harlan Laboratories Report no. 41400265) using the flask method according to the OECD TG 105 (1995) and EU A.6 (Commission Regulation (EC) No 440/2008) protocols. The experiment can be considered relevant and adequate for the endpoint. Therefore it is deemed conclusive and was rated „reliable without restrictions“, i.e. “Klimisch 1” according to the scale of Klimisch et al. (1997).

The test system consisted of purified (reverse osmosis) water. After stirring 24, 48 and 72 h at 30 °C followed by 24 h equilibration at 20.0 ± 0.5 °C, the concentration of test item in the sample solutions was quantified by gas chromatography (GC).

The water solubility was determined to be 35.1 g/L, calculated as the arithmetic mean of three replicates (range 34.8 to 35.5 g/L, standard deviation: ± 1.1 %). According to a scheme (FAO 2000) this result indicates that the submission item should be considered „highly soluble“.

  • FAO Food & Agriculture Organization of the UN (2000). Appendix 2. Parameters of pesticides that influence processes in the soil. In FAO Information Division Editorial Group, ed, FAO Pesticide Disposal Series 8. Assessing Soil Contamination. A Reference Manual. Self-published, Rome, Italy. Available at (Accessed July 29, 2013).
  • Klimisch HJ, Andreae M, Tillmann U (1997). A Systematic Approach for Evaluating the Quality of Experimental Toxicological and Ecotoxicological Data. DOI 10.1006/rtph.1996.1076 PMID 9056496 Regul Toxicol Pharmacol 25:1-5.
  • Walker JA (2014). DMI: Determination of Water Solubility and Flammability (Solids). Harlan Laboratories Ltd., Shardlow Business Park, Shardlow, Derbyshire, DE72 2GD, U.K. Study report no. 41400265. Report date: 2014-04-19