2-Pyridinecarboxylic acid, 4-amino-3,6-dichloro-

Melting point / freezing point

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

17 April 2001 to 5 December 2001

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7200 (Melting Point / Melting Range)

Deviations:

no

GLP compliance:

yes

Type of method:

thermal analysis

Remarks:

- differential scanning calorimetry (DSC)

Specific details on test material used for the study:

Purity: 99.5%

Key result

Melting / freezing pt.:

165.2 °C

Remarks on result:

other: no information on pressure was provided.

Table 1: Summary of Results

Sample	Melting point (°C)	Average (°C)
1	167.13	165.2
2	163.33

Conclusions:

The melting point of the test material was determined to be 165.2 °C, average of two determinations.

Executive summary:

The melting point of the test material was evaluated under GLP conditions and in accordance with the standardised guideline EPA OPPTS 830.7200 by differential scanning calorimtery.

Under the conditions of the study, the melting point of the test material was determined to be 165.2 °C, average of two determinations.

Reference 2

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

30 August 2002 to 15 November 2002

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7200 (Melting Point / Melting Range)

Deviations:

no

GLP compliance:

yes

Type of method:

thermal analysis

Remarks:

- differential scanning calorimetry (DSC)

Specific details on test material used for the study:

Purity: 99.5%

Key result

Melting / freezing pt.:

163.5 °C

Remarks on result:

other: no information on pressure was provided.

The calibration thermograms for the indium, zinc and phenacetin scans all confirmed the proper operation of the DSC. The preliminary scan of the test material at 10 °C/minute showed melting and then decomposition at about 334 °C.

The DSC thermograms from the melting point determinations showed decomposition at the melt point. The first determination showed a 1.2 % weight loss due to decomposition of the sample. The scan of the second determination was halted immediately after the completion of melting in an attempt to minimise the loss due to decomposition. However, the second sample pan still lost 1.7 % of its weight. The sample decomposition did not appear to affect the onset of melting.

The average of the two determinations was reported as the melting point for the test material.

Table 1: Summary of Results

Sample	Melting point (°C)	Average (°C)
1	165.23	163.5
2	161.75

Conclusions:

The melting point of the test material was determined to be 163.5 °C, average of two determinations.

Executive summary:

The melting point of the test material was evaluated under GLP conditions and in accordance with the standardised guideline EPA OPPTS 830.7200 by differential scanning calorimtery.

Under the conditions of the study, the melting point of the test material was determined to be 163.5 °C, average of two determinations.

Decomposition was observed from the melting point prior to final decomposition at ca. 334 °C.

Description of key information

Melting point = 165.2 °C, EPA OPPTS 830.7200 (DSC), Russell (2002)
Melting point = 163.5 °C with decomposition at ca. 334 °C, EPA OPPTS 830.7200 (DSC), Russell (2003) 

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:

163.5 °C

Additional information

Two studies investigating the melting point of the test material are available. Both studies were conducted under GLP conditions and in accordance with the standardised guideline EPA OPPTS 830.7200 by differential scanning calorimetry and were subsequently assigned a reliability score of 1 in line with the criteria of Klimisch et al. (1997).

In the first study (Russell, 2002) the melting point of the test material was determined to be 165.2 °C, average of two determinations.

In the second study (Russell, 2003) the melting point of the test material was determined to be 163.5 °C, average of two determinations. Decomposition was observed from the melting point prior to final decomposition at ca. 334 °C.