Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 926-197-1 | CAS number: -
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24 August 2015-17 November 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-compliant study in accordance with EC A.6 and OECD 105.
Data source
Referenceopen allclose all
- Reference Type:
- other: study amendment
- Title:
- Unnamed
- Year:
- 2 021
- Report date:
- 2021
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- (2008)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- (1995)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- (1998)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
Test material
- Reference substance name:
- 5-[(S)-4-Carboxy-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyrylamino]-2-nitro-benzoic acid
- EC Number:
- 926-197-1
- Cas Number:
- 2561176-48-3
- Molecular formula:
- C20 H15 N3 O9
- IUPAC Name:
- 5-[(S)-4-Carboxy-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyrylamino]-2-nitro-benzoic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name (as cited in study report): P-Glupa-C
- Appearance: yellow powder
- Storage conditions: at room temperature
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- 1.63 g/L
- Temp.:
- 20 °C
- pH:
- 2.4 - 2.5
- Remarks on result:
- other: The substance seems not stable in water.
- Details on results:
- The concentration analysed after 24, 48 and 72 hours of stirring was 0.977 g/L, 0.772 g/L and 0.654 g/L, resp. A decrease in concentration was observed over time indicating degradation. The pH of the aqueous samples was 2.6-2.7. The maximum difference of 40% did not meet the criterion of = 15% .
The concentration analysed after 3, 6 and 16 hours of stirring was 1.65 g/L, 1.62 g/L and 1.05 g/L, resp. The pH of the aqueous samples was 2.4-2.5. The 16-hour measurement was significantly lower than the 3- and 6-hour measurements (maximum difference > 15%). Based on this, the water solubility of the test substance was given as the mean value of the 3- and 6-hour measurements. A maximum difference of 2.2% was calculated over the 3- and 6-hour measurements.
No test substance was detected in the pretreated sample from the blank water mixtures.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): decomposes
In a GLP-compliant study in accordance with EC A.6, OECD 105 and OPPTS 830.7840 using the flask method, a decrease in concentration with stirring time was measured indicating degradation. The water solubility of the substance at 20°C was reported as 1.63 g/L, which is the mean of the concentration analysed after 3 and 6 hours of stirring.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
