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Administrative data

Endpoint:
relative self-ignition temperature (solids)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
24 August 2015-17 November 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP-compliant study in accordance with UN-MTC Section 33.3.1.

Data source

Referenceopen allclose all

Reference Type:
other: study amendment
Title:
Unnamed
Year:
2021
Report date:
2021
Reference Type:
study report
Title:
Unnamed
Year:
2015
Report date:
2015

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: UN ST/SG/AC.10/11/Rev.5: Recommendations on the Transport of Dangerous Goods, Manual of Tests and Criteria, Part III Section 33.3.1 "Substances liable to spontaneous combustion” (2009).
Deviations:
no
Principles of method if other than guideline:
UN MTC Section 33.3.1.4 - Test N.4: Test method for self-heating substances (2009)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
5-[(S)-4-Carboxy-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyrylamino]-2-nitro-benzoic acid
EC Number:
926-197-1
Cas Number:
2561176-48-3
Molecular formula:
C20 H15 N3 O9
IUPAC Name:
5-[(S)-4-Carboxy-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyrylamino]-2-nitro-benzoic acid
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
- Name (as cited in study report): P-Glupa-C
- Appearance: yellow powder
- Storage conditions: at room temperature

Results and discussion

Relative self-ignition temperature (solids)
Key result
Relative self-ignition temperature:
> 140 °C
Remarks on result:
other: A negative result was obtained in the test using a 10 cm sample cube at 140°C: no spontaneous ignition occurred and no exothermic effect was observed.

Any other information on results incl. tables

After the experiment, the consistency of the sample was unchanged, i.e. no reaction and/or decomposition of the test substance was observed.

 

 

 

 

Applicant's summary and conclusion

Conclusions:
In a GLP-compliant study performed in accordance with UN-MTC Section 33.3.1 (Test N.4), a negative result was obtained using a 10 cm sample cube at 140°C. From this it was concluded that the substance is not a self-heating substance.