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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Administrative data

Link to relevant study record(s)

Description of key information

The key study was a static algal growth inhibition test on the effects of trimellitic anhydride on the freshwater alga, Scenedesmus subspicatus, on the basis of read-across based on a grouping of substances (category approach).

Key value for chemical safety assessment

EC50 for freshwater algae:
739 mg/L
EC10 or NOEC for freshwater algae:
739 mg/L

Additional information

The test material trimellitic anhydride was not shown to exhibit toxicity to the freshwater alga, Scenedesmus subspicatus. The 96-h NOEC was reported as ≥ 739 mg/L (measured). The 96-h EC50 was not determined, but is reported here to be > 739 mg/L (measured).

A category approach is used for the assessment of several endpoints. The hypothesis for the category of cyclic acid anhydrides is the similar chemical behaviour and analogous breakdown products in environmental and biological systems. The common functional group is a 1,3-dioxo-1,3-dihydro-2-furan ring (i.e., a cyclic acid anhydride) directly attached to an aromatic ring. The cyclic anhydride moiety is quickly hydrolysed to form a dioic acid. The cyclic acid anhydride moiety and its dioic acid derivatives are the principal loci of toxicity, rather than the remainder of the molecule.Within the category, oligomeric forms of the cyclic acid anhydrides are less likely to be absorbed across biological membranes than the simple, monomeric forms, so that this read-across represents the worst case scenario. For each endpoint study based upon read-across, the category approach is substantiated by an evaluation provided in the Chemical Category Report Format (CCRF) attached to the endpoint study summary file. The CCRF allows the read-across information to fulfil the information requirements of the REACH Annexes VII-X, to be the basis for classification and labelling decisions, and for risk assessment.