Registration Dossier
Registration Dossier
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EC number: 415-490-5 | CAS number: 141773-73-1 HELVETOLIDE
Endpoint summary
Administrative data
Description of key information
The registered substance is not readily biodegradable. However, the key experimental biodegradation study, performed on the C6 isomers of the registered substance, demonstrates that this substance disappears in a ready test and therefore is not considered persistent (non-P). Indeed, total primary biodegradation of the C6 isomers of the registered substance is demonstrated, to form a transformation product (C6 isomers) at 79% and Propionic acid at ca. 20%, but mineralised.
The primary biodegradation is also observed for the C7 isomer of the registered substance, based on QSAR predictions (Catalogic 301C v.08.12).
To conclude on the persistence of the transformation product, a screening non-GLP ready biodegradation study (OECD 301F) was performed on the transformation product (C6 and C7 isomers) and only 0 to 4% biodegradation was observed after 28 days and a prolongation to 60 days, respectively. This result is also confirmed based on QSAR prediction (Catalogic 301C v.08.12). Therefore, the transformation product of the registered substance can be considered as potentially persistent (potential P) or very persistent (potential vP), in the absence of simulation studies.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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