Registration Dossier
Registration Dossier
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EC number: 200-254-4 | CAS number: 56-06-4
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary source
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- 2,6-diamino-1H-pyrimidin-4-one
- EC Number:
- 200-254-4
- EC Name:
- 2,6-diamino-1H-pyrimidin-4-one
- Cas Number:
- 56-06-4
- Molecular formula:
- C4H6N4O
- IUPAC Name:
- 2,6-diamino-1H-pyrimidin-4-one
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Frequency of treatment:
- two treatments
- Post exposure period:
- Sacrifice 24h after the second dose
Doses / concentrations
- Remarks:
- Doses / Concentrations:
2000 mg/kg bw
Basis:
actual ingested
- Control animals:
- yes, concurrent vehicle
- Positive control(s):
- mitomycin C
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- yes
- Remarks:
- clinical signs
- Additional information on results:
- Toxicity to bone marrow, as measured by alteration to the PCE/NCE ratio, was not observed, however the clinical signs shown by two of the test animals indicate that the notified chemical was systemically available
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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