Registration Dossier
Registration Dossier
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EC number: 200-254-4 | CAS number: 56-06-4
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondery (but reliable) source, little details available.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Scientific Opinion on the safety evaluation of the substance, 2,4-diamino-6-hydroxypyrimidine, CAS No. 56-06-4, for use in food contact materials
- Author:
- EFSA
- Year:
- 2 009
- Bibliographic source:
- EFSA Journal 2009; 7(12):1397
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 2,6-diamino-1H-pyrimidin-4-one
- EC Number:
- 200-254-4
- EC Name:
- 2,6-diamino-1H-pyrimidin-4-one
- Cas Number:
- 56-06-4
- Molecular formula:
- C4H6N4O
- IUPAC Name:
- 2,6-diamino-1H-pyrimidin-4-one
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and E. coli WP2
- Metabolic activation:
- with and without
- Metabolic activation system:
- rat liver S9, arochlor-induced
- Test concentrations with justification for top dose:
- a) With metabolic activation: 0 – 2500 µg/plate.
b) Without metabolic activation: 0 - 2500 µg/plate. - Vehicle / solvent:
- DMSO
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and E. coli WP2
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- >2500 ug/ml
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
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