Registration Dossier
Registration Dossier
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EC number: 907-996-4 | CAS number: -
Toxicity to reproduction
Administrative data
- Endpoint:
- two-generation reproductive toxicity
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- For justification of read across see category justification attached to category object.
Data source
Materials and methods
Test material
- Reference substance name:
- 2-(2-(2-butoxyethoxy)ethoxy)ethanol
- EC Number:
- 205-592-6
- EC Name:
- 2-(2-(2-butoxyethoxy)ethoxy)ethanol
- Cas Number:
- 143-22-6
- Molecular formula:
- C10H22O4
- IUPAC Name:
- 2-(2-(2-Butoxyethoxy)ethoxy)ethanol
- Reference substance name:
- 205-22-6
- IUPAC Name:
- 205-22-6
- Reference substance name:
- 2-(2-(2-butoxy)ethoxy)ethanol
- IUPAC Name:
- 2-(2-(2-butoxy)ethoxy)ethanol
- Details on test material:
- Name of test material (as cited in study report): 2-(2-(2-butoxy)ethoxy)ethanol
Analytical purity: purity 79.5%
Constituent 1
Constituent 2
Constituent 3
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
- Dose descriptor:
- NOAEC
- Effect level:
- > 1 000 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- male/female
- Remarks on result:
- other: Current available data from category members suggests no adverse effects would be seen up to the limit dose shown.
Target system / organ toxicity (P0)
- Critical effects observed:
- no
Results: P1 (second parental generation)
Effect levels (P1)
- Dose descriptor:
- NOAEC
- Effect level:
- 1 000 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- male/female
- Remarks on result:
- other: Current available data from category members suggests no adverse effects would be seen up to the limit dose shown.
Target system / organ toxicity (P1)
- Critical effects observed:
- no
Results: F1 generation
Effect levels (F1)
- Dose descriptor:
- NOAEC
- Generation:
- F1
- Effect level:
- > 1 000 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- male/female
- Remarks on result:
- other: Current available data from category members suggests no adverse effects would be seen up to the limit dose shown.
Target system / organ toxicity (F1)
- Critical effects observed:
- no
Results: F2 generation
Effect levels (F2)
- Remarks on result:
- not measured/tested
Overall reproductive toxicity
- Reproductive effects observed:
- no
Applicant's summary and conclusion
- Executive summary:
Current available data from category members suggests no adverse effects would be seen up to the limit dose shown.
There is no data on the toxicity to reproduction for this substance. A testing proposal has been submitted for the substance 2 -(2 -(2-methoxyethoxy)ethoxy)ethanol and the results will be read across to this substance using a category approach with appropriate additional bridging studies that are currently in progress.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
