Registration Dossier
Registration Dossier
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EC number: 907-996-4 | CAS number: -
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- sub-chronic toxicity: dermal
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Justification for type of information:
- For justification of read across see category justification attached to category object.
Data source
Materials and methods
Test material
- Reference substance name:
- 2-(2-(2-butoxyethoxy)ethoxy)ethanol
- EC Number:
- 205-592-6
- EC Name:
- 2-(2-(2-butoxyethoxy)ethoxy)ethanol
- Cas Number:
- 143-22-6
- Molecular formula:
- C10H22O4
- IUPAC Name:
- 2-(2-(2-Butoxyethoxy)ethoxy)ethanol
- Reference substance name:
- 3,6,9,12-tetraoxahexadecan-1-ol
- EC Number:
- 216-322-1
- EC Name:
- 3,6,9,12-tetraoxahexadecan-1-ol
- Cas Number:
- 1559-34-8
- Molecular formula:
- C12H26O5
- IUPAC Name:
- 3,6,9,12-tetraoxahexadecan-1-ol
Constituent 1
Constituent 2
Results and discussion
Effect levels
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- Dose descriptor:
- NOAEL
- Effect level:
- 5 000 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: All other effects other than local irritation
- Remarks on result:
- other: based on a weighted average consideration of the results for this substance based on other substances within the category. Results corrected for molecular weight differences.
- Remarks:
- There is no data on the repeat dose toxicity of this substance from studies to modern guidelines. A sub-acute bridging study is being carried out on this substance to add confidence to bridging between members of this category
- Dose descriptor:
- NOAEL
- Effect level:
- 500 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- dermal irritation
- Remarks on result:
- other: based on a weighted average consideration of the results for this substance based on other substances within the category. Results corrected for molecular weight differences.
- Remarks:
- There is no data on the repeat dose toxicity of this substance from studies to modern guidelines. A sub-acute bridging study is being carried out on this substance to add confidence to bridging between members of this category
Target system / organ toxicity
- Critical effects observed:
- no
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
