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Registration Dossier
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EC number: 907-996-4 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: restriction: early study report; short study description. Otherwise scientifically reliable
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 966
- Report date:
- 1966
Materials and methods
- Principles of method if other than guideline:
- Estimation of the approximative LD50 value according to BASF-internal standard
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-(2-(2-butoxyethoxy)ethoxy)ethanol
- EC Number:
- 205-592-6
- EC Name:
- 2-(2-(2-butoxyethoxy)ethoxy)ethanol
- Cas Number:
- 143-22-6
- Molecular formula:
- C10H22O4
- IUPAC Name:
- 2-(2-(2-Butoxyethoxy)ethoxy)ethanol
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: US rats
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Observation period: 14 days
Test substance given as 2, 20 and 30% aqueous solution - Doses:
- 200, 1600, 3200, 4000, 5000, 6400 ccm/kg
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- approximate LD50
- Effect level:
- ca. 5 170 mg/kg bw
- Sex:
- male/female
- Dose descriptor:
- approximate LD50
- Effect level:
- ca. 5.2 mL/kg bw
- Remarks on result:
- other: original value
- Mortality:
- see table below
- Clinical signs:
- other: Staggering, abdominal and lateral position, narcosis; female rats: sometimes bloody urine
- Gross pathology:
- sometimes bloody urine, several kidney damage
Any other information on results incl. tables
| Dose (cmm/kg) | Conc. (%) | No. of animals | Dead animals within | ||||
| 1 hour | 24 hours | 48 hours | 7 days | 14 days | |||
| 6400 | 30 | 10 | 5/10 | 9/10 | 9/10 | 9/10 | 9/10 |
| 5000 | 30 | 10 | 0/10 | 5/10 | 5/10 | 5/10 | 5/10 |
| 30 | 10 | 1/10 | 3/10 | 3/10 | 3/10 | 3/10 | |
| 4000 | 30 | 10 | 0/10 | 1/10 | 1/10 | 1/10 | 1/10 |
| 30 | 10 | 2/10 | 4/10 | 5/10 | 5/10 | 5/10 | |
| 3200 | 30 | 10 | 1/10 | 1/10 | 2/10 | 2/10 | 2/10 |
| 1600 | 20 | 10 | 0/10 | 0/10 | 0/10 | 0/10 | 0/10 |
| 200 | 2 | 10 | 0/10 | 0/10 | 0/10 | 0/10 | 0/10 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Executive summary:
In a reliable acute oral toxicity study where original data is available, male and female rats were subjected to doses of up to 6400ml/kg of 2-(2-(2-butoxyethoxy)ethoxy)ethanol and subsequently observed for a period of 14 days. An LD50 value of ~5170mg/kg was obtained.
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