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Diss Factsheets

Physical & Chemical properties

Melting point / freezing point

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Administrative data

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
25-08-2009 / 21-10-2009
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results. The study report was conclusive, done to a valid guideline and the study was conducted under GLP conditions.
Cross-reference
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2009
Report date:
2009

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
Qualifier:
according to guideline
Guideline:
other: Council Regulation (EC) No. 440/2008, 30 May 2008, Part A, Methods for the determination of physico-chemical properties, A.1 Melting/Freezing temperature and A.2 Boiling temperature
Deviations:
no
GLP compliance:
yes
Type of method:
thermal analysis
Remarks:
via DSC

Test material

Constituent 1
Reference substance name:
RS-Pantolactone
IUPAC Name:
RS-Pantolactone
Constituent 2
Chemical structure
Reference substance name:
(±)-dihydro-3-hydroxy-4,4-dimethylfuran-2(3H)-one
EC Number:
201-210-7
EC Name:
(±)-dihydro-3-hydroxy-4,4-dimethylfuran-2(3H)-one
Cas Number:
79-50-5
Molecular formula:
C6H10O3
IUPAC Name:
(±)-dihydro-3-hydroxy-4,4-dimethylfuran-2(3H)-one
Details on test material:
- Name of test material (as cited in study report): RS-Pantolactone
- Physical state: Waxy Solid, white
- Analytical purity: 99.7 %
- Lot/batch No.: Bx TL 00905003
- Expiration date of the lot/batch: May 2011
- Storage condition of test material: At room temperature at about 20 °C

Results and discussion

Melting / freezing point
Melting / freezing pt.:
70.4 °C
Atm. press.:
98.9 kPa
Decomposition:
no
Sublimation:
no

Any other information on results incl. tables

The determinations of the melting point / melting range of the test item were performed according to Council Regulation (EC) No. 440/2008, A.1 Melting/Freezing temperature and to the OECD Guideline No. 102: Melting point / melting range adopted July 27, 1995.

 

Preliminary Test

Several endothermic heat effects were observed, the first peak starting at 66.5 °C. After the experiment, the sample had lost about 100% of its mass. The cup was empty and there was no residue.

 

 

Main Test

Melting Point / Melting Range

In order to determine the melting more precisely, further DSC-runs were recorded between 50 °C and 90 °C with a heating rate of 10 °C/min. In the first main test run, the melting was observed at 70.4 °C, during the second main test run at 70.5 °C. During these runs, the sample lost about 0.8% to 1.0% weight and the sample was molten and looked milky.

 

The results of the individual measurements are summarized in the table below

Applicant's summary and conclusion

Conclusions:
The melting point of RS-Pantolactone was determined to be

70.4 °C,
which is equal to 343.6 K.

The estimated accuracy is ± 0.5 K.

Executive summary:

The melting point of RS-Pantolactone was determined to be 70.4 °C which is equal to 343.6 K using the thermal analysis (DSC).

 

The atmospheric pressure during the measurements was 98.9 kPa.