Registration Dossier
Registration Dossier
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EC number: 810-533-8 | CAS number: 330459-31-9
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Under the study conditions, NOEC and LOEC for the test substance, based on mean, measured test concentrations, and post-hatch survival were 9.4 and 24 μg a.i./L, respectively.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.009 mg/L
Additional information
A study was conducted to determine the effect of the test substance on the time to hatch, hatching success, survival, and growth of fathead minnows,Pimephales promelas, during early life-stage development, according to ASTM Standard E-1241 -05, FIFRA Subdivision E, Section 72 -4a, OECD Guideline 210 and OPPTS 850.1400, in compliance with GLP.Fathead minnow embryos were exposed to a geometric series of six test concentrations of 0.26, 0.64, 1.6, 4.0, 10 and 25 μg a.i./L (mean, measured concentrations of 0.23, 0.59, 1.5, 3.7, 9.4 and 24 μg a.i./L), a negative (dilution water) control and a solvent control (0.02 mL/L HPLC-grade dimethylformamide) under flow-through conditions. The exposure period included a 5 d embryo hatching period, and a 28 d post-hatch juvenile growth period.No statistically significant treatment related effect on hatching success was found at 24 μg a.i./L. A statistically significant reduction in post-hatch survival was found at 24 μg a.i./L. There were no significant treatment-related effects on growth at concentrations ≤9.4 μg a.i./L. Under the study conditions, NOEC and LOEC for the test substance, based on mean, measured test concentrations, and post-hatch survival were 9.4 and 24 μg a.i./L, respectively. The maximum acceptable toxicant concentration (MATC) was calculated to be 15 μg a.i./L (Minderhout T, 2013).
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