Registration Dossier
Registration Dossier
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EC number: 224-166-0 | CAS number: 4221-80-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Only short summary available, but results are reported sufficiently for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 964
- Report date:
- 1964
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,4-di-tert-butylphenyl 3,5-di-tert-butyl-4-hydroxybenzoate
- EC Number:
- 224-166-0
- EC Name:
- 2,4-di-tert-butylphenyl 3,5-di-tert-butyl-4-hydroxybenzoate
- Cas Number:
- 4221-80-1
- Molecular formula:
- C29H42O3
- IUPAC Name:
- 2,4-di-tert-butylphenyl 3,5-di-tert-butyl-4-hydroxybenzoate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: suspension of dimethylsulfoxide/propylene glycol
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 10000 mg/kg
DOSAGE PREPARATION:
The test substance was prepared as a suspension in 25 % dimethylsulfoxide/75% propylene glycol, containing the compound at a concentration equivalent to 2500 mg/kg. The 5000 mg/kg level was attained by dosing with 2 times the volume at 2500 mg/kg; 10000 mg/kg by dosing twice at 5000 mg/kg with a 3 hr interval between doses. - Doses:
- 1250, 2500, 5000 and 10000 mg/kg
- No. of animals per sex per dose:
- 5 animals per group (sex not specified)
- Control animals:
- not specified
- Details on study design:
- no data
Results and discussion
- Preliminary study:
- none
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no mortality
- Clinical signs:
- no data
- Body weight:
- no data
- Gross pathology:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 was greater than 10000 mg/kg bw
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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