Registration Dossier
Registration Dossier
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EC number: 205-860-2 | CAS number: 156-60-5
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Negative results were observed in an in vitro gene mutation study in bacterial cells (Salmonella typhimurium and E. coli), an in vitro gene mutation study in mammalian cells (Chinese hamster ovary cells), an in vitro cytogenicity study in mammalian cells (Chinese hamster ovary cells), and an in vivo micronucleus (mouse bone marrow) study. Overall, the test substance is considered negative for genotoxicity.
Short description of key information:
In Vitro (Mutagenic effects - bacterial): OECD 471; Bacterial reverse mutation assay. Negative. Reliability = 1.
In Vitro (Clastogenic effects - mammalian): OECD 473; Chinese hamster ovary cells. Negative. Reliability = 2
In Vitro (Mutagenic effects - mammalian): OECD 476; Mammalian Cell Forward Gene Mutation (CHO/HPRT) Assay . Negative. Reliability = 1
In Vivo (Clastogenic effects - mammalian): OECD 474; in vivo mouse micronucleus study; Negative. Reliability = 1.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Overall, the test substance is negative for genotoxicity when evaluated in bacterial or mammalian cell cultures or in laboratory animals. Based on an assessment of the robust genetic toxicity data for this substance, the substance does not need to be classified for mutagenicity according the EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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