Registration Dossier
Registration Dossier
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EC number: 200-755-8 | CAS number: 71-48-7
Toxicity to soil macroorganisms except arthropods
Administrative data
- Endpoint:
- toxicity to soil macroorganisms except arthropods: long-term
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study, peer reviewed, no analytical dose verification.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Dietary cobalt supplements and the growth and reproduction of the earthworm Eisenia foetida
- Author:
- Neuhauser EF et al.
- Year:
- 1 984
- Bibliographic source:
- Soil Biology and Biochemistry 16: 521–523
- Reference Type:
- secondary source
- Title:
- CICAD 69, Cobalt and inorganic cobalt compounds
- Author:
- WHO
- Year:
- 2 006
Materials and methods
- Principles of method if other than guideline:
- Reproduction and growth test, 24 weeks
- GLP compliance:
- no
Test material
- Reference substance name:
- Cobalt dichloride, hexahydrate
- IUPAC Name:
- Cobalt dichloride, hexahydrate
- Reference substance name:
- 7791-13-1
- EC Number:
- 616-574-6
- Cas Number:
- 7791-13-1
- IUPAC Name:
- 7791-13-1
- Details on test material:
- - Analytical purity: no data
Constituent 1
Constituent 2
Sampling and analysis
- Analytical monitoring:
- no
Test substrate
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Eisenia fetida
- Animal group:
- annelids
Study design
- Study type:
- laboratory study
- Substrate type:
- natural soil
- Limit test:
- no
- Total exposure duration:
- 24 wk
Test conditions
- Nominal and measured concentrations:
- 9.4, 17.6, 25.9, 91.9 µg Co g-1 d.w. in horse manure
- Reference substance (positive control):
- no
Results and discussion
Any other information on results incl. tables
The authors observed significantly increased maximum weights compared to the control worms which were exposed to 9.4 µg Co g-1. The highest Co addition (82.5 µg Co g-1, total 91.9 µg Co g-1) caused no increase in maximum weight over controls, but resulted in a statistically significant lag in early growth compared to that of all other groups. Significantly more cocoons were produced by worms fed 17.6 or 25.9 µg Co g-1 compared with those fed 9.4 or 91.9 µg Co g-1.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
