N-butyl 4-oxopentanoate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because exposure of humans via inhalation is not likely taking into account the vapour pressure of the substance and/or the possibility of exposure to aerosols, particles or droplets of an inhalable size

Cross-reference

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

0,005 kPa at 25 °C

Vapour pressure:

0.005 kPa

at the temperature of:

25 °C

Available literature data were used for the evaluation of the vapour pressiure of the substance.

In one of the studies, an electrically heated modification of the Ramsay and Young type of apparatus was used to determine the vapor pressure. Duplicate runs of about twenty-five readings were made. Pressures were read on a closed manometer which had been corrected by reference to a standard barometer. The relation between boiling temperatures and vapor pressures of the substance was shown by calculating the appropriate constants for the Kirchhoff formula and the resulting equation was log P = 27.0531 -5.970 log T-4089.1/T. Some decomposition of the substance was observed during the latter part of each run, as shown by the fact that a small amount of carbonaceous residue was formed at the place of evaporation. The vapour pressure of the substance at 25 °C is calculated as 0.005 kPa.

The vapour pressure of the substance was further determined using a Fischer–Labodest all-glass dynamic recirculating still, which was equipped with a Cottrell pump. The temperatures were measured by means of a model F25 thermometer with a PT100 probe from Automatic Systems Laboratories, and the pressures in the still were measured with a Digiquartz 735-215A-102 pressure transducer from Paroscientific. The vapour pressure of the substance at 110 °C is 1.460 kPa.