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EC number: 700-008-0 | CAS number: 3753-18-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Vapour pressure
Administrative data
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Testing was conducted between 05 January 2009 and 15 January 2009.anuary 2009 and 15 January 2009.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of relevant results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- (Schedule 1, Good Laboratory Practice Regulations 1999 (SI 1999/3106 as amended by SI 2004/0994)). Date of sinpection: 21/08/2008. Date of signature: 04/03/2009.
- Type of method:
- effusion method: vapour pressure balance
Test material
- Reference substance name:
- 4,4'-bis(methoxymethyl)-1,1'-biphenyl
- EC Number:
- 700-008-0
- Cas Number:
- 3753-18-2
- Molecular formula:
- C16 H18 O2
- IUPAC Name:
- 4,4'-bis(methoxymethyl)-1,1'-biphenyl
- Reference substance name:
- 4,4-bis(methoxymethyl)-biphenyl
- IUPAC Name:
- 4,4-bis(methoxymethyl)-biphenyl
Constituent 1
Constituent 2
Results and discussion
Vapour pressure
- Temp.:
- 25 °C
- Vapour pressure:
- 0 Pa
Transition / decomposition
- Transition / decomposition:
- no
Any other information on results incl. tables
Results
Run1
Temperature (ºC) |
Temperature (K) |
Reciprocal Temperature (K-1) |
Mass Difference (µg) |
Mass Difference (kg) |
Vapour Pressure (Pa) |
Log10Vp |
35 |
308.15 |
0.003245173 |
1.03 |
1.030E-09 |
0.001429904 |
-2.844693154 |
36 |
309.15 |
0.003234676 |
1.24 |
1.240E-09 |
0.001721438 |
-2.764108694 |
37 |
310.15 |
0.003224246 |
1.75 |
1.750E-09 |
0.002429448 |
-2.614492330 |
38 |
311.15 |
0.003213884 |
2.27 |
2.270E-09 |
0.003151342 |
-2.501504522 |
39 |
312.15 |
0.003203588 |
2.78 |
2.780E-09 |
0.003859352 |
-2.413485583 |
40 |
313.15 |
0.003193358 |
3.50 |
3.500E-09 |
0.004858897 |
-2.313462334 |
41 |
314.15 |
0.003183193 |
3.91 |
3.910E-09 |
0.005428082 |
-2.265353621 |
42 |
315.15 |
0.003173092 |
4.63 |
4.630E-09 |
0.006427626 |
-2.191949388 |
A plot of Log10(vapour pressure (Pa)) versus reciprocal temperature (1/T(K)) for Run 1 gives the following statistical data using an unweighted least squares treatment.
Slope -9318.209
Standard deviation in slope 481.838
Intercept 27.413
Standard deviation in intercept 1.546
The results obtained indicate the following vapour pressure relationship:
Log10(Vp (Pa)) = -9318.209/temp(K) + 27.413
The above yields a vapour pressure (Pa) at 298.15 K with a common logarithm of -3.841.
Run 2
Temperature (ºC) |
Temperature (K) |
Reciprocal Temperature (K-1) |
Mass Difference (µg) |
Mass Difference (kg) |
Vapour Pressure (Pa) |
Log10Vp |
36 |
309.15 |
0.003234676 |
1.54 |
1.540E-09 |
0.002137915 |
-2.670009658 |
37 |
310.15 |
0.003224246 |
1.85 |
1.850E-09 |
0.002568274 |
-2.590358650 |
38 |
311.15 |
0.003213884 |
2.27 |
2.270E-09 |
0.003151342 |
-2.501504522 |
39 |
312.15 |
0.003203588 |
2.88 |
2.880E-09 |
0.003998178 |
-2.398137891 |
40 |
313.15 |
0.003193358 |
3.81 |
3.810E-09 |
0.005289256 |
-2.276605403 |
41 |
314.15 |
0.003183193 |
4.02 |
4.020E-09 |
0.005580790 |
-2.253304326 |
42 |
315.15 |
0.003173092 |
4.53 |
4.530E-09 |
0.006288801 |
-2.201432177 |
A plot of Log10(vapour pressure (Pa)) versus reciprocal temperature (1/T(K)) for Run 2 gives the following statistical data using an unweighted least squares treatment.
Slope -8024.254
Standard deviation in slope 552.540
Intercept 23.294
Standard deviation in intercept 1.770
The results obtained indicate the following vapour pressure relationship:
Log10(Vp (Pa)) = -8024.254/temp(K) + 23.294
The above yields a vapour pressure (Pa) at 298.15 K with a common logarithm of -3.619.
Run 3
Temperature (ºC) |
Temperature (K) |
Reciprocal Temperature (K-1) |
Mass Difference (µg) |
Mass Difference (kg) |
Vapour Pressure (Pa) |
Log10Vp |
35 |
308.15 |
0.003245173 |
1.03 |
1.030E-09 |
0.001429904 |
-2.844693154 |
36 |
309.15 |
0.003234676 |
1.34 |
1.340E-09 |
0.001860263 |
-2.730425580 |
37 |
310.15 |
0.003224246 |
1.65 |
1.650E-09 |
0.002290623 |
-2.640046435 |
38 |
311.15 |
0.003213884 |
2.27 |
2.270E-09 |
0.003151342 |
-2.501504522 |
39 |
312.15 |
0.003203588 |
2.68 |
2.680E-09 |
0.003720527 |
-2.429395585 |
40 |
313.15 |
0.003193358 |
3.30 |
3.300E-09 |
0.004581245 |
-2.339016439 |
41 |
314.15 |
0.003183193 |
3.91 |
3.910E-09 |
0.005428082 |
-2.265353621 |
A plot of Log10(vapour pressure (Pa)) versus reciprocal temperature (1/T(K)) for Run 3 gives the following statistical data using an unweighted least squares treatment.
Slope -9447.292
Standard deviation in slope 352.587
Intercept 27.828
Standard deviation in intercept 1.133
The results obtained indicate the following vapour pressure relationship:
Log10(Vp (Pa)) = -9447.292/temp(K) + 27.828
The above yields a vapour pressure (Pa) at 298.15 K with a common logarithm of -3.858.
Run 4
Temperature (ºC) |
Temperature (K) |
Reciprocal Temperature (K-1) |
Mass Difference (µg) |
Mass Difference (kg) |
Vapour Pressure (Pa) |
Log10Vp |
33 |
306.15 |
0.003266373 |
0.51 |
5.100E-10 |
0.000708011 |
-3.149960203 |
34 |
307.15 |
0.003255738 |
0.72 |
7.200E-10 |
0.000999544 |
-3.000197882 |
35 |
308.15 |
0.003245173 |
1.03 |
1.030E-09 |
0.001429904 |
-2.844693154 |
36 |
309.15 |
0.003234676 |
1.54 |
1.540E-09 |
0.002137915 |
-2.670009658 |
37 |
310.15 |
0.003224246 |
1.85 |
1.850E-09 |
0.002568274 |
-2.590358650 |
38 |
311.15 |
0.003213884 |
2.37 |
2.370E-09 |
0.003290167 |
-2.482782033 |
39 |
312.15 |
0.003203588 |
3.09 |
3.090E-09 |
0.004289712 |
-2.367571899 |
A plot of Log10(vapour pressure (Pa)) versus reciprocal temperature (1/T(K)) for Run 4 gives the following statistical data using an unweighted least squares treatment.
Slope -12417.416
Standard deviation in slope 591.114
Intercept 37.439
Standard deviation in intercept 1.912
The results obtained indicate the following vapour pressure relationship:
Log10(Vp (Pa)) = -12417.416/temp(K) + 37.439
The above yields a vapour pressure (Pa) at 298.15 K with a common logarithm of -4.210.
Run 5
Temperature (ºC) |
Temperature (K) |
Reciprocal Temperature (K-1) |
Mass Difference (µg) |
Mass Difference (kg) |
Vapour Pressure (Pa) |
Log10Vp |
33 |
306.15 |
0.003266373 |
0.41 |
4.100E-10 |
0.000569185 |
-3.244746522 |
34 |
307.15 |
0.003255738 |
0.51 |
5.100E-10 |
0.000708011 |
-3.149960203 |
35 |
308.15 |
0.003245173 |
0.72 |
7.200E-10 |
0.000999544 |
-3.000197882 |
36 |
309.15 |
0.003234676 |
1.34 |
1.340E-09 |
0.001860263 |
-2.730425580 |
37 |
310.15 |
0.003224246 |
1.75 |
1.750E-09 |
0.002429448 |
-2.614492330 |
38 |
311.15 |
0.003213884 |
2.16 |
2.160E-09 |
0.002998633 |
-2.523076628 |
39 |
312.15 |
0.003203588 |
2.99 |
2.990E-09 |
0.004150886 |
-2.381859190 |
A plot of Log10(vapour pressure (Pa)) versus reciprocal temperature (1/T(K)) for Run 5 gives the following statistical data using an unweighted least squares treatment.
Slope -14434.604
Standard deviation in slope 886.309
Intercept 43.887
Standard deviation in intercept 2.867
The results obtained indicate the following vapour pressure relationship:
Log10(Vp (Pa)) = -14434.604/temp(K) + 43.887
The above yields a vapour pressure (Pa) at 298.15 K with a common logarithm of -4.527.
Run 6
Temperature (ºC) |
Temperature (K) |
Reciprocal Temperature (K-1) |
Mass Difference (µg) |
Mass Difference (kg) |
Vapour Pressure (Pa) |
Log10Vp |
34 |
307.15 |
0.003255738 |
0.62 |
6.200E-10 |
0.000860719 |
-3.065138689 |
35 |
308.15 |
0.003245173 |
0.72 |
7.200E-10 |
0.000999544 |
-3.000197882 |
36 |
309.15 |
0.003234676 |
1.24 |
1.240E-09 |
0.001721438 |
-2.764108694 |
37 |
310.15 |
0.003224246 |
1.75 |
1.750E-09 |
0.002429448 |
-2.614492330 |
38 |
311.15 |
0.003213884 |
2.37 |
2.370E-09 |
0.003290167 |
-2.482782033 |
39 |
312.15 |
0.003203588 |
2.99 |
2.990E-09 |
0.004150886 |
-2.381859190 |
40 |
313.15 |
0.003193358 |
3.71 |
3.710E-09 |
0.005150430 |
-2.288156469 |
A plot of Log10(vapour pressure (Pa)) versus reciprocal temperature (1/T(K)) for Run 6 gives the following statistical data using an unweighted least squares treatment.
Slope -13227.824
Standard deviation in slope 819.748
Intercept 39.995
Standard deviation in intercept 2.643
The results obtained indicate the following vapour pressure relationship:
Log10(Vp (Pa)) = -13227.824/temp(K) + 39.995
The above yields a vapour pressure (Pa) at 298.15 K with a common logarithm of -4.371.
Summary of Results
Run |
Log10[Vp(25ºC)] |
1 |
-3.841 |
2 |
-3.619 |
3 |
-3.858 |
4 |
-4.210 |
5 |
-4.527 |
6 |
-4.371 |
Mean |
-4.071 |
Vapour Pressure |
8.5 x 10-5Pa |
The test material did not change in appearance under the conditions used in the determination.
Applicant's summary and conclusion
- Conclusions:
- The vapour pressure of the test material has been determined to be 8.5 x 10-5 Pa at 25ºC.
- Executive summary:
The vapour pressure was determined using a vapour pressure balance with measurements being made at several temperatures and linear regression analysis used to calculate the vapour pressure at 25°C. Testing was conducted using Method A4 Vapour Pressure of Council Regulation (EC) No 440/2208 of 30 May 2008, Part A: Methods for the determination of physico-chemical properties.
The vapour pressure of the test material has been determined to be 8.5 x 10-5Pa at 25ºC.
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