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REACH

4,4-bis(methoxymethyl)biphenyl

EC number: 700-008-0 | CAS number: 3753-18-2

Life Cycle description
Uses advised against

Physical & Chemical properties

Vapour pressure

Administrative data

Endpoint:: vapour pressure
Type of information:: experimental study
Adequacy of study:: key study
Study period:: Testing was conducted between 05 January 2009 and 15 January 2009.anuary 2009 and 15 January 2009.
Reliability:: 1 (reliable without restriction)
Rationale for reliability incl. deficiencies:: other: Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of relevant results.

Data source

Reference

Reference Type:: study report
Title:: Unnamed
Year:: 2009
Report date:: 2009

Materials and methods

Test guideline

Qualifier:: according to guideline
Guideline:: EU Method A.4 (Vapour Pressure)
Deviations:: no

GLP compliance:: yes (incl. QA statement)
Remarks:: (Schedule 1, Good Laboratory Practice Regulations 1999 (SI 1999/3106 as amended by SI 2004/0994)). Date of sinpection: 21/08/2008. Date of signature: 04/03/2009.
Type of method:: effusion method: vapour pressure balance

Test material

Test material information

Constituent 1

Reference substance name:: 4,4'-bis(methoxymethyl)-1,1'-biphenyl
EC Number:: 700-008-0
Cas Number:: 3753-18-2
Molecular formula:: C16 H18 O2
IUPAC Name:: 4,4'-bis(methoxymethyl)-1,1'-biphenyl

Constituent 2

Reference substance name:: 4,4-bis(methoxymethyl)-biphenyl
IUPAC Name:: 4,4-bis(methoxymethyl)-biphenyl

Results and discussion

Vapour pressure

Temp.:: 25 °C
Vapour pressure:: 0 Pa

Transition / decomposition

Transition / decomposition:: no

Any other information on results incl. tables

Results

Run1

Temperature (ºC)	Temperature (K)	Reciprocal Temperature (K^-1)	Mass Difference (µg)	Mass Difference (kg)	Vapour Pressure (Pa)	Log₁₀Vp
35	308.15	0.003245173	1.03	1.030E-09	0.001429904	-2.844693154
36	309.15	0.003234676	1.24	1.240E-09	0.001721438	-2.764108694
37	310.15	0.003224246	1.75	1.750E-09	0.002429448	-2.614492330
38	311.15	0.003213884	2.27	2.270E-09	0.003151342	-2.501504522
39	312.15	0.003203588	2.78	2.780E-09	0.003859352	-2.413485583
40	313.15	0.003193358	3.50	3.500E-09	0.004858897	-2.313462334
41	314.15	0.003183193	3.91	3.910E-09	0.005428082	-2.265353621
42	315.15	0.003173092	4.63	4.630E-09	0.006427626	-2.191949388

A plot of Log₁₀(vapour pressure (Pa)) versus reciprocal temperature (1/T(K)) for Run 1 gives the following statistical data using an unweighted least squares treatment.

Slope -9318.209
Standard deviation in slope 481.838

Intercept 27.413
Standard deviation in intercept 1.546

The results obtained indicate the following vapour pressure relationship:

Log₁₀(Vp (Pa)) = -9318.209/temp(K) + 27.413

The above yields a vapour pressure (Pa) at 298.15 K with a common logarithm of -3.841.

Run 2

Temperature (ºC)	Temperature (K)	Reciprocal Temperature (K^-1)	Mass Difference (µg)	Mass Difference (kg)	Vapour Pressure (Pa)	Log₁₀Vp
36	309.15	0.003234676	1.54	1.540E-09	0.002137915	-2.670009658
37	310.15	0.003224246	1.85	1.850E-09	0.002568274	-2.590358650
38	311.15	0.003213884	2.27	2.270E-09	0.003151342	-2.501504522
39	312.15	0.003203588	2.88	2.880E-09	0.003998178	-2.398137891
40	313.15	0.003193358	3.81	3.810E-09	0.005289256	-2.276605403
41	314.15	0.003183193	4.02	4.020E-09	0.005580790	-2.253304326
42	315.15	0.003173092	4.53	4.530E-09	0.006288801	-2.201432177

A plot of Log₁₀(vapour pressure (Pa)) versus reciprocal temperature (1/T(K)) for Run 2 gives the following statistical data using an unweighted least squares treatment.

Slope -8024.254
Standard deviation in slope 552.540

Intercept 23.294
Standard deviation in intercept 1.770

The results obtained indicate the following vapour pressure relationship:

Log₁₀(Vp (Pa)) = -8024.254/temp(K) + 23.294

The above yields a vapour pressure (Pa) at 298.15 K with a common logarithm of -3.619.

Run 3

Temperature (ºC)	Temperature (K)	Reciprocal Temperature (K^-1)	Mass Difference (µg)	Mass Difference (kg)	Vapour Pressure (Pa)	Log₁₀Vp
35	308.15	0.003245173	1.03	1.030E-09	0.001429904	-2.844693154
36	309.15	0.003234676	1.34	1.340E-09	0.001860263	-2.730425580
37	310.15	0.003224246	1.65	1.650E-09	0.002290623	-2.640046435
38	311.15	0.003213884	2.27	2.270E-09	0.003151342	-2.501504522
39	312.15	0.003203588	2.68	2.680E-09	0.003720527	-2.429395585
40	313.15	0.003193358	3.30	3.300E-09	0.004581245	-2.339016439
41	314.15	0.003183193	3.91	3.910E-09	0.005428082	-2.265353621

A plot of Log₁₀(vapour pressure (Pa)) versus reciprocal temperature (1/T(K)) for Run 3 gives the following statistical data using an unweighted least squares treatment.

Slope -9447.292
Standard deviation in slope 352.587

Intercept 27.828
Standard deviation in intercept 1.133

The results obtained indicate the following vapour pressure relationship:

Log₁₀(Vp (Pa)) = -9447.292/temp(K) + 27.828

The above yields a vapour pressure (Pa) at 298.15 K with a common logarithm of -3.858.

Run 4

Temperature (ºC)	Temperature (K)	Reciprocal Temperature (K^-1)	Mass Difference (µg)	Mass Difference (kg)	Vapour Pressure (Pa)	Log₁₀Vp
33	306.15	0.003266373	0.51	5.100E-10	0.000708011	-3.149960203
34	307.15	0.003255738	0.72	7.200E-10	0.000999544	-3.000197882
35	308.15	0.003245173	1.03	1.030E-09	0.001429904	-2.844693154
36	309.15	0.003234676	1.54	1.540E-09	0.002137915	-2.670009658
37	310.15	0.003224246	1.85	1.850E-09	0.002568274	-2.590358650
38	311.15	0.003213884	2.37	2.370E-09	0.003290167	-2.482782033
39	312.15	0.003203588	3.09	3.090E-09	0.004289712	-2.367571899

A plot of Log₁₀(vapour pressure (Pa)) versus reciprocal temperature (1/T(K)) for Run 4 gives the following statistical data using an unweighted least squares treatment.

Slope -12417.416
Standard deviation in slope 591.114

Intercept 37.439
Standard deviation in intercept 1.912

The results obtained indicate the following vapour pressure relationship:

Log₁₀(Vp (Pa)) = -12417.416/temp(K) + 37.439

The above yields a vapour pressure (Pa) at 298.15 K with a common logarithm of -4.210.

Run 5

Temperature (ºC)	Temperature (K)	Reciprocal Temperature (K^-1)	Mass Difference (µg)	Mass Difference (kg)	Vapour Pressure (Pa)	Log₁₀Vp
33	306.15	0.003266373	0.41	4.100E-10	0.000569185	-3.244746522
34	307.15	0.003255738	0.51	5.100E-10	0.000708011	-3.149960203
35	308.15	0.003245173	0.72	7.200E-10	0.000999544	-3.000197882
36	309.15	0.003234676	1.34	1.340E-09	0.001860263	-2.730425580
37	310.15	0.003224246	1.75	1.750E-09	0.002429448	-2.614492330
38	311.15	0.003213884	2.16	2.160E-09	0.002998633	-2.523076628
39	312.15	0.003203588	2.99	2.990E-09	0.004150886	-2.381859190

A plot of Log₁₀(vapour pressure (Pa)) versus reciprocal temperature (1/T(K)) for Run 5 gives the following statistical data using an unweighted least squares treatment.

Slope -14434.604
Standard deviation in slope 886.309

Intercept 43.887
Standard deviation in intercept 2.867

The results obtained indicate the following vapour pressure relationship:

Log₁₀(Vp (Pa)) = -14434.604/temp(K) + 43.887

The above yields a vapour pressure (Pa) at 298.15 K with a common logarithm of -4.527.

Run 6

Temperature (ºC)	Temperature (K)	Reciprocal Temperature (K^-1)	Mass Difference (µg)	Mass Difference (kg)	Vapour Pressure (Pa)	Log₁₀Vp
34	307.15	0.003255738	0.62	6.200E-10	0.000860719	-3.065138689
35	308.15	0.003245173	0.72	7.200E-10	0.000999544	-3.000197882
36	309.15	0.003234676	1.24	1.240E-09	0.001721438	-2.764108694
37	310.15	0.003224246	1.75	1.750E-09	0.002429448	-2.614492330
38	311.15	0.003213884	2.37	2.370E-09	0.003290167	-2.482782033
39	312.15	0.003203588	2.99	2.990E-09	0.004150886	-2.381859190
40	313.15	0.003193358	3.71	3.710E-09	0.005150430	-2.288156469

A plot of Log₁₀(vapour pressure (Pa)) versus reciprocal temperature (1/T(K)) for Run 6 gives the following statistical data using an unweighted least squares treatment.

Slope -13227.824
Standard deviation in slope 819.748

Intercept 39.995
Standard deviation in intercept 2.643

The results obtained indicate the following vapour pressure relationship:

Log₁₀(Vp (Pa)) = -13227.824/temp(K) + 39.995

The above yields a vapour pressure (Pa) at 298.15 K with a common logarithm of -4.371.

Summary of Results

Run	Log₁₀[Vp(25ºC)]
1	-3.841
2	-3.619
3	-3.858
4	-4.210
5	-4.527
6	-4.371
Mean	-4.071
Vapour Pressure	8.5 x 10^-5Pa

The test material did not change in appearance under the conditions used in the determination.

Applicant's summary and conclusion

Conclusions:

The vapour pressure of the test material has been determined to be 8.5 x 10-5 Pa at 25ºC.

Executive summary:

The vapour pressure was determined using a vapour pressure balance with measurements being made at several temperatures and linear regression analysis used to calculate the vapour pressure at 25°C. Testing was conducted using Method A4 Vapour Pressure of Council Regulation (EC) No 440/2208 of 30 May 2008, Part A: Methods for the determination of physico-chemical properties.

The vapour pressure of the test material has been determined to be 8.5 x 10^-5Pa at 25ºC.

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