4,4-bis(methoxymethyl)biphenyl

Particle size distribution (Granulometry)

Administrative data

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Testing was conducted between 17 December 2008 and 27 January 2009.

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of relevant results.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2009

Report date:

2009

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

UK GLP standards (Schedule 1, Good Laboratory Practice Regulations 1999 (SI 1999/3106 as amended by SI 2004/0994)). Date of inspection: 21/08/2008. Date of signature: 04/03/2009

Type of distribution:

counted distribution

Test material

Test material information

Constituent 1

Reference substance name:

4,4'-bis(methoxymethyl)-1,1'-biphenyl

EC Number:

700-008-0

Cas Number:

3753-18-2

Molecular formula:

C16 H18 O2

IUPAC Name:

4,4'-bis(methoxymethyl)-1,1'-biphenyl

Constituent 2

Reference substance name:

4,4-bis(methoxymethyl)-biphenyl

IUPAC Name:

4,4-bis(methoxymethyl)-biphenyl

Results and discussion

Particle size

Percentile:

D50

Remarks on result:

other: Migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.

Particle size distribution at different passages

No.:

#1

Size:

> 0.1 - < 100 µm

Distribution:

2.34 %

Any other information on results incl. tables

 Screening test (sieve method)

The results of the sieving procedure are shown in the following table:

Sieve aperture size (µm)	100
Mass of test material transferred to sieve (g)	10.68
Mass of test material passed through sieve (g)	0.25
Test material less than sieve aperture size (%)	2.34

 

Applicant's summary and conclusion

Conclusions:

The proportion of test material having an inhalable particle size less than 100 µm was 2.34 %. The test material is essentially non-inhalable.

Executive summary:

The method used is designed to comply with that given in ‘Particle Size Distribution, Fibre Length and Diameter Distribution’, June 1996 European Commission technical guidance document, which satisfies the requirements of OECD Guideline 110.

The proportion of test material having an inhalable particle size less than 100 µm was 2.34 %. The test material is essentially non-inhalable.