Registration Dossier
Registration Dossier
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EC number: 223-912-2 | CAS number: 4118-16-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979-10-05-1979-12-03
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1,1'-[(6-phenyl-1,3,5-triazine-2,4-diyl)diimino]bisanthraquinone
- EC Number:
- 223-912-2
- EC Name:
- 1,1'-[(6-phenyl-1,3,5-triazine-2,4-diyl)diimino]bisanthraquinone
- Cas Number:
- 4118-16-5
- Molecular formula:
- C37H21N5O4
- IUPAC Name:
- 1,1'-[(6-phenyl-1,3,5-triazine-2,4-diyl)diimino]di(9,10-anthraquinone)
Constituent 1
Test animals
- Species:
- hamster, Chinese
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 4-6 weeks old
- Weight at study initiation: 27-37g
- Housing: Individually in Macrolon cages
- Diet: NAFAG, Gossau SG, ad libitum
- Drinking water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 2°C
- Humidity (%): 55 +/- 10 %
- Photoperiod: 10 hours light
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Details on oral exposure:
- DOSAGE PREPARATION: The test item was suspended to achieve the corresponding dosage level. Before treatment the suspension was homogeneously dispersed with an Ultra-Turrax and during treatment it was kept stable with a magnetic stirrer.
Volume: 10 and 20 mL/kg body weight - Doses:
- 3000, 4000, 5000, 6000 mg/kg bw
- No. of animals per sex per dose:
- 5 male
5 female - Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: Bodyweight: Immediately prior to dosing and after 7 and 14 days.
Clinical observations: Daily
Results and discussion
- Preliminary study:
- none
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 6 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no mortality
- Clinical signs:
- other: Total recovery within 7-8 days Sedation: Slight effects, recovery after 2 days (3000 mg/kg) Slight effects, recovery after 5 days (all other dose groups) Dyspnoe: Slight effects, recovery after 7 days (3000 mg/kg) Slight effects, recovery after 6 days
- Gross pathology:
- No substance related gross organ changes were seen.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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