Registration Dossier
Registration Dossier
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EC number: 942-741-0 | CAS number: -
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: fragrance mixture as test substance
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Subchronic inhalation studies of complex fragrance mixtures in rats and hamsters
- Author:
- Fukayama MY et al.
- Year:
- 1 999
- Bibliographic source:
- Toxicology Letters 111: 175-187, 1999
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Fukayama MY et al.
- Year:
- 2 003
- Bibliographic source:
- RIFM Database
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Eight complex fragrance mixtures consisting of approximately 200 ingredients (close to one-half of the ingredients present at a level of 1% or more) were tested in rats and hamsters.
Methyl ionone was present in 7 out of the eight mixtures.
Animals were whole-body exposed to the mixtures at 5, 9 or 50 mg/m³.
Exposure was 6 or 13 weeks, 4h daily, 5 days per week. - GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- (1E)-1-(2,6,6-trimethylcyclohex-2-en-1-yl)pent-1-en-3-one; (3E)-3-methyl-4-(2,6,6-trimethylcyclohex-2-en-1-yl)but-3-en-2-one
- EC Number:
- 942-741-0
- Cas Number:
- 1335-46-2
- Molecular formula:
- C14H22O
- IUPAC Name:
- (1E)-1-(2,6,6-trimethylcyclohex-2-en-1-yl)pent-1-en-3-one; (3E)-3-methyl-4-(2,6,6-trimethylcyclohex-2-en-1-yl)but-3-en-2-one
1
- Specific details on test material used for the study:
- - Other: fragrance mixture as test substance
Test animals
- Species:
- other: rats and hamsters
- Strain:
- other: CD rats, Sprague-Dawley rats, syrian hamster
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Remarks on MMAD:
- MMAD / GSD: 0.5 - 7.5 µm
- Duration of treatment / exposure:
- 6 or 13 weeks
- Frequency of treatment:
- daily 4 h , 5 days a week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
5, 9, 50 mg/m3
Basis:
nominal conc.
- Details on study design:
- Post-exposure period: none
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Haematological findings:
- no effects observed
- Clinical biochemistry findings:
- no effects observed
- Urinalysis findings:
- no effects observed
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Gross pathological findings:
- no effects observed
- Histopathological findings: non-neoplastic:
- no effects observed
Effect levels
- Dose descriptor:
- NOEL
- Effect level:
- 50 mg/m³ air
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
