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Physical & Chemical properties

Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1995-07-27 to 1995-07-28
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
The study was conducted according to an internationally recognised method, and under GLP. No deviation affected the quality of the study. Purity is specified in the report, and isomers composition is available from the notifier. Therefore full validation applies.
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
Commission Directive 92/69/EEC
GLP compliance:
yes (incl. QA statement)
Remarks:
Inspected on 31 January 1994. Signed on 16 March 1994
Type of method:
effusion method: vapour pressure balance
Key result
Temp.:
25 °C
Vapour pressure:
0.04 Pa
Run 1
°C K 1/T (K-1) Pa log P (Pa)
36 309.15 0.00323468 0.181347907 -0.7415
37 310.15 0.00322425 0.206072750 -0.6860
38 311.15 0.00321388 0.225952579 -0.6460
39 312.15 0.00320359 0.260992165 -0.5834
40 313.15 0.00319336 0.287577272 -0.5412
41 314.15 0.00318319 0.315314630 -0.5013
42 315.15 0.00317309 0.352991904 -0.4522
43 316.15 0.00316306 0.385768632 -0.4137
44 317.15 0.00315308 0.428637984 -0.3679
45 318.15 0.00314317 0.485750844 -0.3136
46 319.15 0.00313332 0.537741039 -0.2694
47 320.15 0.00312354 0.601614706 -0.2207

The measurements gave the regression for run 1:

Log10VP (Pa) = -4607.763 / T (K) + 14.168

Error in slope is 45.672 (0.99%) and error in intercept is 0.145 (1.02%).

Coefficient of determination was calculated from the above data: R2 = 0.9990

Run 2
°C K 1/T (K-1) Pa log P (Pa)
48 321.15 0.00311381 0.483224218 -0.3159
47 320.15 0.00312354 0.434149361 -0.3624
46 319.15 0.00313332 0.397055155 -0.4011
45 318.15 0.00314317 0.348063594 -0.4583
44 317.15 0.00315308 0.306402026 -0.5137
43 316.15 0.00316306 0.273403176 -0.5632
42 315.15 0.00317309 0.243541785 -0.6134
41 314.15 0.00318319 0.216123725 -0.6653
40 313.15 0.00319336 0.194869523 -0.7103
39 312.15 0.00320359 0.177474672 -0.7509
38 311.15 0.00321388 0.157830847 -0.8018
37 310.15 0.00322425 0.144003815 -0.8416
36 309.15 0.00323468 0.128635819 -0.8906
35 308.15 0.00324517 0.113073467 -0.9466
34 307.15 0.00325574 0.102425542 -0.9896
33 306.15 0.00326637 0.092416215 -1.0343
32 305.15 0.00327708 0.083475845 -1.0784
31 304.15 0.00328785 0.077492461 -1.1107
30 303.15 0.0032987 0.072536386 -1.1394
29 302.15 0.00330961 0.064442853 -1.1908
28 301.15 0.0033206 0.058737120 -1.2311
27 300.15 0.00333167 0.052073490 -1.2834
26 299.15 0.0033428 0.047839309 -1.3202

The measurements gave the regression for run 2:

Log10VP (Pa) = -4399.336 / T (K) + 13.356

Error in slope is 58.616 (1.33%) and error in intercept is 0.189 (1.42%).

Coefficient of determination was calculated from the above data: R2= 0.9963

Run 3
°C K 1/T (K-1) Pa log P (Pa)
26 299.15 0.0033428 0.036386195 -1.4391
27 300.15 0.00333167 0.038732348 -1.4119
28 301.15 0.0033206 0.040745319 -1.3899
29 302.15 0.00330961 0.044118782 -1.3554
30 303.15 0.0032987 0.046714821 -1.3305
31 304.15 0.00328785 0.050935120 -1.2930
32 305.15 0.00327708 0.054489056 -1.2637
33 306.15 0.00326637 0.060111493 -1.2210
34 307.15 0.00325574 0.063526604 -1.1970
35 308.15 0.00324517 0.067025009 -1.1738
36 309.15 0.00323468 0.074313354 -1.1289
37 310.15 0.00322425 0.080171795 -1.0960
38 311.15 0.00321388 0.086307888 -1.0639
39 312.15 0.00320359 0.096803105 -1.0141
40 313.15 0.00319336 0.109908243 -0.9590
41 314.15 0.00318319 0.124207282 -0.9059
42 315.15 0.00317309 0.129066179 -0.8892
43 316.15 0.00316306 0.143268040 -0.8439
44 317.15 0.00315308 0.156734125 -0.8048
45 318.15 0.00314317 0.171810587 -0.7650
46 319.15 0.00313332 0.183596882 -0.7361
47 320.15 0.00312354 0.195230469 -0.7095
48 321.15 0.00311381 0.209099149 -0.6796
49 322.15 0.00310414 0.223009476 -0.6517
50 323.15 0.00309454 0.230339468 -0.6376

The measurements gave the regression for run 3:

Log10VP (Pa) = -3452.622 / T (K) + 10.064

Error in slope is 53.446 (1.55%) and error in intercept is 0.172 (1.71%).

Coefficient of determination was calculated from the above data: R2= 0.9945

The following results were obtained from the regression equations:

Run Log10 VP (25°C)
1 -1.287
2 -1.400
3 -1.516
mean -1.401
Vapour pressure (Pa) 4.0 x 10-2

The test material did not change in apperance under the conditions used in the determination.

Conclusions:
Low volatility (based on volatility bands criteria for occupational exposure (Chesar / ECETOC TRA), << 500 Pa).
Executive summary:

The vapour pressure of the test substance was measured under GLP according to EU A4 guideline, vapour pressure balance method.

Three runs were performed, with respectively 12 measurements recorded between 36 and 47°C, 23 measurements recorded between 48 and 26°C, and 25 measurements recorded between 26 and 50°C. The slope and intercept of the linear relashionship betweenlog VP and 1/T were calculated for each run.

Vapour pressure at 25°C was derived from the mean log VP extrapolated from these equations, as 0.040 Pa.

Description of key information

Low volatility.

Key value for chemical safety assessment

Vapour pressure:
0.04 Pa
at the temperature of:
25 °C

Additional information

A fully reliable experimental study, conducted according to a recognized EC method and under GLP, is available. Therefore, it is considered as a key study. Measurements were performed between 26 and 50°C, and the extrapolated result at 25°C is retained as key value.

It should be noted that, due to the multi-isomers nature of the substance, this result may refer to the most volatile one.