Registration Dossier
Registration Dossier
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EC number: 807-130-4 | CAS number: 53716-82-8
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance has a low potential for bioaccumulation based on log Kow <=3 and a low potential to cross biological membranes
Reference
Description of key information
Bioaccumulation (Cyrene™/Gem Diol): Low potential for bioaccumulation
Key value for chemical safety assessment
Additional information
When CyreneTM is in aqueous solution, the keto group (C=O) gains water (H2O) to form the corresponding Gem Diol {(1S,5R)-6,8-dioxabicyclo[3.2.1]octane-4,4-diol}. An equilibrium is established rapidly (meaning that the reaction is rapidly reversible). The ratio of the two forms is dependent upon the amount of water present (see attached document in Section 13 for further details). At concentrations relevant for the environment (aquatic media) and in vivo, the Gem Diol form predominates. A log Kow value of -1.52 at 22.0 ± 1.0°C and pH 5.18 to 5.24 was determined for Cyrene™/Gem Diol. Therefore, the submission substance has low potential for bioaccumulation.
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