Registration Dossier
Registration Dossier
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EC number: 224-832-0 | CAS number: 4511-42-6
Surface tension
Administrative data
- Endpoint:
- surface tension
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Modern GLP study. Note that lactide hydrolyses in aqueous solution with a half life @ 20°C and pH = 7 of 1.45 h. Hydrolysis lowers the pH and thereby speeds up the hydrolysis rate. Therefore, hydrolysis rates will also increase at higher concentrations. As such, measuring the surface tension of lactide solutions is not particularly relevant, as the solution will have reverted to a solution of lactic acid in a couple of hours. As such, the determination of the surface tension of a solution of lactic acid is more relevant.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 115 (Surface Tension of Aqueous Solutions)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.5 (Surface Tension)
- Deviations:
- no
- GLP compliance:
- not specified
- Type of method:
- OECD harmonised ring method
Test material
- Reference substance name:
- (3S-cis)-3,6-dimethyl-1,4-dioxane-2,5-dione
- EC Number:
- 224-832-0
- EC Name:
- (3S-cis)-3,6-dimethyl-1,4-dioxane-2,5-dione
- Cas Number:
- 4511-42-6
- Molecular formula:
- C6H8O4
- IUPAC Name:
- 3,6-dimethyl-1,4-dioxane-2,5-dione
Constituent 1
Results and discussion
Surface tension
- Surface tension:
- 70.7 mN/m
- Temp.:
- 20 °C
- Conc.:
- 1 g/L
Applicant's summary and conclusion
- Conclusions:
- A standardized test for the surface tension of lactic acid resulted in the determination that a 1g/L solution of lactic acid in water has a surface tension of 70.7 mN/m; at this surface tension, it can be concluded that lactic acid is not a surface active substance. Since a molecule of lactide will ultimately result in 2 molecules lactic acid
- Executive summary:
A standardized test for the surface tension of lactic acid resulted in the determination that a 1g/L solution of lactic acid in water has a surface tension of 70.7 mN/m; at this surface tension, it can be concluded that lactic acid is not a surface active substance.
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