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Registration Dossier
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EC number: 200-831-0 | CAS number: 75-01-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Available data indicate that vinyl chloride is absorbed rapidly and virtually completely absorbed following inhalation and oral exposure. Dermal absorption of gaseous vinyl chloride is not significant. After a 2 -2.5 h exposure of rhesus monkeys to 800 and 7000 ppm vinyl chloride, dermal absorption was estimated to be 0.031% and 0.023% of total bioavailable vinyl chloride, respectively.
In rats, absorbed vinyl chloride is distributed primarily to the liver and skin.
Metabolism is believed to proceed via different pathways, the extent of which is dependent on vinyl chloride concentrations. At low concentrations, vinyl chloride is oxidized sequentially to 2-chloroethanol, 2-chloroacetaldehyde and 2 -chloroacetic acid by alcohol dehydrogenase, while at higher concentrations it is metabolized by liver cytochrome P-450 IIE1 to the reactive oxirane, 2 -chloroethylene oxide and its rearrangement product 2-chloroacetaldehyde. Chloroethylene oxide and chloroacetaldehyde react with nucleic acid bases, forming DNA adducts, which are thought to play a role in carcinogenicity of vinyl chloride.
The elimination of vinyl chloride follows first-order kinetics. At low exposure levels, the majority is excreted into the urine, while at higher exposure levels, the proportion of exhaled unmetabolized vinyl chloride increases.
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