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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

The 96-h LC50 is 210 mg/l in the fresh water species Brachydanio rerio tested according OECD 203 (Groeneveld, 1993)

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
210 mg/L

Additional information

A GLP-compliant OECD 203 guideline test was available and the 96-h LC50 value of vinyl chloride in Brachydanio rerio is 210 mg/l (Groeneveld, 1993). This value is used in the assessment, because the other two experimental studies that are available are older non-GLP studies with higher LC50 values (Industrial Bio-Test laboratories, Inc., 1971). Furthermore, calculated effect concentrations using ECOSAR are available for freshwater fish (U.S. EPA, 2000). The calculation of 115 mg/l is reliable, validated and falls within the applicability domain of the QSAR.