Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 215-687-4 | CAS number: 1344-09-8
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-guideline study with sufficient detail.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Antitesticular effect of metallic and rare earth salts.
- Author:
- Kamboj, V. P. and Kar, A. B.
- Year:
- 1 964
- Bibliographic source:
- J. Reprod. Fertil. 7, 21-28
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
- Principles of method if other than guideline:
- Type: other: male reproduction organs
Method: other: no guideline was followed - GLP compliance:
- no
- Type of method:
- in vivo
Test material
- Reference substance name:
- Silicic acid, sodium salt
- EC Number:
- 215-687-4
- EC Name:
- Silicic acid, sodium salt
- Cas Number:
- 1344-09-8
- Molecular formula:
- Na2O x (SiO2)n with Molar Ratio (MR) (SiO2/Na2O): 1.5 – 4
- IUPAC Name:
- sodium hydroxy(oxo)silanolate
- Details on test material:
- SOURCE: Not indicated
PURITY: Not indicated
IMPURITY/ADDITIVE/ETC.: Not indicated
ANY OTHER INFORMATION: Molar ratio not indicated
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: swiss albino
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ORGANISMS
- weight at study initiation: 100-120 g
Administration / exposure
- Route of administration:
- other: intratesticularly or subcutaneously
- Vehicle:
- water
- Details on exposure:
- - Total volume applied: 0.2 mL
- Duration of treatment / exposure:
- once
- Frequency of treatment:
- once
- Duration of test:
- 7 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.08 mmole/kg bw
Basis:
- Control animals:
- yes, concurrent vehicle
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 0.08 other: mmole/kg bw
- Sex:
- male
Any other information on results incl. tables
TOXIC RESPONSE/EFFECTS BY DOSE LEVEL: - Morphology: no alteration of the rat testis. - Histology: no alteration of the rat testis. - Organ weight: slight reduction in testis weight. - Spermatozoa: no effect on spermatozoa in the ductus deferens of the rats.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
